Donnelly A E, McCormick K, Maughan R J, Whiting P H, Clarkson P M
Department of Environmental & Occupational Medicine, University Medical School, Aberdeen, Scotland.
Br J Sports Med. 1988 Mar;22(1):35-8. doi: 10.1136/bjsm.22.1.35.
Twenty untrained male volunteers were required to run downhill for 45 minutes on a motor driven treadmill to induce muscle soreness. The volunteers took diclofenac or placebo before and for 72 hours after two runs 10 weeks apart, in a randomised double blind crossover design. Subjective soreness was assessed before and at intervals up to 72 hours after each run; venous blood samples, collected at the same time intervals, were used to estimate serum activities of creatine kinase, lactate dehydrogenase and aspartate aminotransferase and serum concentrations of creatinine and urea. Subjective soreness and the biochemical parameters increased after both runs, although the serum enzyme response to the second run was reduced. Diclofenac had no influence on the serum biochemical response to downhill running. Although overall soreness was not affected by diclofenac, individual soreness measurements were reduced by diclofenac at the first period of the study. These results suggest that diclofenac does not influence muscle damage, but may slightly reduce the associated soreness.
20名未经训练的男性志愿者被要求在电动跑步机上进行45分钟的下坡跑以诱发肌肉酸痛。志愿者们在间隔10周的两次跑步前及跑步后72小时服用双氯芬酸或安慰剂，采用随机双盲交叉设计。在每次跑步前及跑步后直至72小时的间隔时间评估主观酸痛感；在相同时间间隔采集静脉血样，用于测定肌酸激酶、乳酸脱氢酶和天冬氨酸转氨酶的血清活性以及肌酐和尿素的血清浓度。两次跑步后主观酸痛感和生化参数均升高，尽管第二次跑步后血清酶反应有所降低。双氯芬酸对下坡跑后的血清生化反应没有影响。虽然双氯芬酸对总体酸痛感没有影响，但在研究的第一阶段，双氯芬酸使个体酸痛测量值降低。这些结果表明，双氯芬酸不影响肌肉损伤，但可能会略微减轻相关的酸痛感。
