School of Life Sciences, Precision Medicine Institute, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510060, China.
State Key Laboratory of Oncology in South China, Cancer Center, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou 510060, China.
Nucleic Acids Res. 2022 Jul 5;50(W1):W420-W426. doi: 10.1093/nar/gkac373.
The visualization of biological sequences with various functional elements is fundamental for the publication of scientific achievements in the field of molecular and cellular biology. However, due to the limitations of the currently used applications, there are still considerable challenges in the preparation of biological schematic diagrams. Here, we present a professional tool called IBS 2.0 for illustrating the organization of both protein and nucleotide sequences. With the abundant graphical elements provided in IBS 2.0, biological sequences can be easily represented in a concise and clear way. Moreover, we implemented a database visualization module in IBS 2.0, enabling batch visualization of biological sequences from the UniProt and the NCBI RefSeq databases. Furthermore, to increase the design efficiency, a resource platform that allows uploading, retrieval, and browsing of existing biological sequence diagrams has been integrated into IBS 2.0. In addition, a lightweight JS library was developed in IBS 2.0 to assist the visualization of biological sequences in customized web services. To obtain the latest version of IBS 2.0, please visit https://ibs.renlab.org.
用各种功能元件可视化生物序列对于在分子和细胞生物学领域发表科学成果是至关重要的。然而，由于目前使用的应用程序存在局限性，在准备生物示意图方面仍然存在相当大的挑战。在这里，我们介绍了一个名为 IBS 2.0 的专业工具，用于说明蛋白质和核苷酸序列的组织。IBS 2.0 提供了丰富的图形元素，可以轻松简洁地表示生物序列。此外，我们在 IBS 2.0 中实现了数据库可视化模块，能够从 UniProt 和 NCBI RefSeq 数据库批量可视化生物序列。此外，为了提高设计效率，我们将一个允许上传、检索和浏览现有生物序列图的资源平台集成到 IBS 2.0 中。此外，我们在 IBS 2.0 中开发了一个轻量级的 JS 库，以协助在自定义 Web 服务中可视化生物序列。要获取 IBS 2.0 的最新版本，请访问 https://ibs.renlab.org。
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