Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, the Netherlands; Integrative Model-based Cognitive Neuroscience Research Unit, Department of Psychology, University of Amsterdam, the Netherlands; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Wellcome Centre for Human Neuroimaging, University College London, UK.
Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Neuroimage. 2022 Aug 15;257:119320. doi: 10.1016/j.neuroimage.2022.119320. Epub 2022 May 14.
The subthalamic nucleus (STN) is a primary target for deep brain stimulation in Parkinson's disease (PD). Although small in size, the STN is commonly partitioned into sensorimotor, cognitive/associative, and limbic subregions based on its structural connectivity profile to cortical areas. We investigated whether such a regional specialization is also supported by functional connectivity between local field potential recordings and simultaneous magnetoencephalography. Using a novel data set of 21 PD patients, we replicated previously reported cortico-STN coherence networks in the theta/alpha and beta frequency ranges, and looked for the spatial distribution of these networks within the STN region. Although theta/alpha and beta coherence peaks were both observed in on-medication recordings from electrode contacts at several locations within and around the STN, sites with theta/alpha coherence peaks were situated at significantly more inferior MNI coordinates than beta coherence peaks. Sites with only theta/alpha coherence peaks, i.e. without distinct beta coherence, were mostly located near the border of sensorimotor and cognitive/associative subregions as defined by a tractography-based atlas of the STN. Peak coherence values were largely unaltered by the medication state of the subject, however, theta/alpha peaks were more often identified in recordings obtained after administration of dopaminergic medication. Our findings suggest the existence of a frequency-specific topography of cortico-STN coherence within the STN, albeit with considerable spatial overlap between functional networks. Consequently, optimization of deep brain stimulation targeting might remain a trade-off between alleviating motor symptoms and avoiding adverse neuropsychiatric side effects.
底丘脑核（STN）是帕金森病（PD）深部脑刺激的主要靶点。尽管体积较小，但根据其与皮质区域的结构连接模式，STN 通常被分为感觉运动、认知/联想和边缘亚区。我们研究了这种局部专门化是否也得到局部场电位记录和同时进行的脑磁图之间的功能连接的支持。使用一个新的 21 名 PD 患者的数据集合，我们复制了以前在 theta/alpha 和 beta 频率范围内报告的皮质-STN 相干网络，并在 STN 区域内寻找这些网络的空间分布。尽管在药物治疗期间，来自 STN 内和周围几个位置的电极记录都观察到了 theta/alpha 和 beta 相干峰，但 theta/alpha 相干峰的位置明显低于 beta 相干峰的位置。只有 theta/alpha 相干峰的位置，即没有明显的 beta 相干峰，大多位于感觉运动和认知/联想亚区的边界附近，这是根据 STN 的基于轨迹的图谱定义的。峰值相干值在很大程度上不受被试药物状态的影响，然而，theta/alpha 峰值在给予多巴胺能药物后获得的记录中更常被识别。我们的发现表明，尽管在功能网络之间存在相当大的空间重叠，但 STN 内皮质-STN 相干存在频率特异性的拓扑结构。因此，深部脑刺激靶点的优化可能仍然是缓解运动症状和避免不良神经精神副作用之间的权衡。
