Leng Chuan, Gibney Katherine A, Liu Yuwei, Tew Gregory N, Chen Zhan
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Department of Polymer Science and Engineering, Conte Research Center, University of Massachusetts, Amherst, Massachusetts 01003, United States.
ACS Macro Lett. 2013 Nov 19;2(11):1011-1015. doi: 10.1021/mz400503z. Epub 2013 Oct 30.
Antibiofouling materials have a wide range of applications in biomedical devices and marine coatings. Due to the amphiphilic nature of proteins and organisms, amphiphilic materials have been designed to resist their unspecific adsorption. Surface restructuring behavior of amphiphilic materials in water is believed to play a key role in the antibiofouling mechanisms. In this work, the surface structures of several amphiphilic polybetaine coatings in water have been probed in situ using sum frequency generation (SFG) vibrational spectroscopy. These are novel polybetaines constructed from functionalized polynorbornenes. The polybetaines with oligo(ethylene glycol) (OEG), octyl (C8), or fluorinated (F13) side chains exhibit different surface restructuring behaviors upon contacting water due to their different surface hydrophobicity. The OEG and C8 chains were present and ordered at the water interface, while the F13 chain withdrew from water. The hydrophilic betaine group extended into the water and formed hydrogen bonds with water molecules. The surface restructuring of these materials detected using SFG can be well correlated to their antibiofouling performance, providing an understanding of their antibiofouling mechanisms.
抗生物污染材料在生物医学设备和海洋涂层中有着广泛的应用。由于蛋白质和生物体具有两亲性，人们设计了两亲性材料来抵抗它们的非特异性吸附。两亲性材料在水中的表面重构行为被认为在抗生物污染机制中起关键作用。在这项工作中，使用和频振动光谱（SFG）原位探测了几种两亲性聚甜菜碱涂层在水中的表面结构。这些是由功能化聚降冰片烯构建的新型聚甜菜碱。带有聚乙二醇（OEG）、辛基（C8）或氟化（F13）侧链的聚甜菜碱由于其不同的表面疏水性，在与水接触时表现出不同的表面重构行为。OEG和C8链存在于水界面并有序排列，而F13链从水中撤出。亲水性甜菜碱基团延伸到水中并与水分子形成氢键。使用SFG检测到的这些材料的表面重构与其抗生物污染性能密切相关，有助于理解它们的抗生物污染机制。
