Li Hongyang, Sun Peng
State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Antioxidants (Basel). 2022 Jun 2;11(6):1107. doi: 10.3390/antiox11061107.
Bovine mastitis is a common inflammatory disease, mainly induced by bacterial pathogens, such as , and . Mastitis has negative effects on the production and quality of milk, resulting in huge economic losses. Melatonin, which is synthesized and secreted by the pineal gland and other organs, is ubiquitous throughout nature and has different effects on different tissues. Melatonin is crucial in modulating oxidative stress, immune responses, and cell autophagy and apoptosis, via receptor-mediated or receptor-independent signaling pathways. The potent antioxidative and anti-inflammatory activities of melatonin and its metabolites suggest that melatonin can be used to treat various infections. This article reviews the potential for melatonin to alleviate bovine mastitis through its pleiotropic effect on reducing oxidative stress, inhibiting pro-inflammatory cytokines, and regulating the activation of NF-κB, STATs, and their cascade reactions. Therefore, it is promising that melatonin supplementation may be an alternative to antibiotics for the treatment of bovine mastitis.
牛乳腺炎是一种常见的炎症性疾病，主要由细菌病原体如[此处原文缺失具体细菌名称]、[此处原文缺失具体细菌名称]和[此处原文缺失具体细菌名称]引起。乳腺炎对牛奶的产量和质量有负面影响，导致巨大的经济损失。褪黑素由松果体和其他器官合成与分泌，在自然界中广泛存在，对不同组织有不同影响。褪黑素通过受体介导或非受体依赖的信号通路，在调节氧化应激、免疫反应以及细胞自噬和凋亡方面至关重要。褪黑素及其代谢产物强大的抗氧化和抗炎活性表明，褪黑素可用于治疗各种感染。本文综述了褪黑素通过其多效性作用减轻牛乳腺炎的潜力，包括降低氧化应激、抑制促炎细胞因子以及调节核因子κB（NF-κB）、信号转导和转录激活因子（STATs）及其级联反应的激活。因此，补充褪黑素有望成为治疗牛乳腺炎的抗生素替代品。
