Center for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital affiliated to Tongji University School of Medicine, Shanghai 200065, China.
The Institute for Translational Nanomedicine, Shanghai East Hospital, Shanghai 200120, China.
Nano Lett. 2022 Jun 8;22(11):4519-4527. doi: 10.1021/acs.nanolett.2c01334. Epub 2022 May 18.
Depression is one of the most fatal mental diseases, and there is currently a lack of efficient drugs for the treatment of depression. Emerging evidence has indicated oxidative stress as a key pathological feature of depression. We targeted reactive oxygen species (ROS) and synthesized CeO@BSA nanoclusters as a novel antidepression nanodrug a convenient, green, and highly effective bovine serum albumin (BSA) incubation strategy. CeO@BSA has ultrasmall size (2 nm) with outstanding ROS scavenging and blood-brain barrier crossing capacity, rapid metabolism, and negligible adverse effects and . CeO@BSA administration alleviates depressive behaviors and depression-related pathological changes of the chronic restraint stress-induced depressive model, suggesting promising therapeutic effects of CeO@BSA for the treatment of depression. Our study proved the validity by directly using nanodrugs as antidepression drugs instead of using them as a nanocarrier, which greatly expands the application of nanomaterials in depression treatment.
抑郁症是最致命的精神疾病之一，目前治疗抑郁症的有效药物还很缺乏。新出现的证据表明氧化应激是抑郁症的一个关键病理特征。我们针对活性氧（ROS），并合成了 CeO@BSA 纳米簇作为一种新型的抗抑郁纳米药物，这是一种方便、绿色、高效的牛血清白蛋白（BSA）孵育策略。CeO@BSA 具有超小的尺寸（2nm），具有出色的 ROS 清除能力和血脑屏障穿透能力，快速代谢，且副作用极小，而且。CeO@BSA 的给药可减轻慢性束缚应激诱导的抑郁模型中的抑郁行为和与抑郁相关的病理变化，表明 CeO@BSA 治疗抑郁症有很有前景的治疗效果。我们的研究通过直接使用纳米药物作为抗抑郁药物而不是将其用作纳米载体来证明其有效性，这大大扩展了纳米材料在抑郁症治疗中的应用。
