Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.
Department of Public Health, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; Health Information Management and Risk Assessment Unit, World Health Emergencies Programme, World Health Organization Region for Africa, Kinshasa, Democratic Republic of the Congo.
Diabetes Res Clin Pract. 2022 Jun;188:109924. doi: 10.1016/j.diabres.2022.109924. Epub 2022 May 15.
Better knowledge of the global metabolic syndrome (MetS) prevalence and its components is a prerequisite to curb the related burden.
We systematically searched PubMed, EMBASE, Web of Knowledge, Africa Journal Online, Global Index Medicus up to May 23, 2021. Prevalence pooling was done with a random-effects meta-analysis.
In total, 1,129 prevalence data (28,193,768 participants) were included. The MetS global prevalence varied from 12.5% (95 %CI: 10.2-15.0) to 31.4% (29.8-33.0) according to the definition considered. The prevalence was significantly higher in Eastern Mediterranean Region and Americas and increased with country's level of income. The global prevalence was 45.1% (95 %CI: 42.1-48.2) for ethnic-specific central obesity, 42.6% (40.3-44.9) for systolic blood pressure (BP) ≥ 130 mmHg and/or diastolic BP ≥ 85 mmHg, 40.2% (37.8-42.5) for HDL-cholesterol < 1.03 for men or < 1.29 mmol/L for women, 28.9% (27.4-30.5) for serum triglycerides ≥ 1.7 mmol/L, and 24.5% (22.5-26.6) for fasting plasma glucose ≥ 5.6 mmol/L.
This study reveals that MetS and its related cardiometabolic components are highly prevalent worldwide. This study calls for more aggressive and contextualized public health interventions to tackle these conditions.
更好地了解全球代谢综合征 (MetS) 的患病率及其组成部分是遏制相关负担的前提。
我们系统地检索了 PubMed、EMBASE、Web of Knowledge、Africa Journal Online 和 Global Index Medicus，截至 2021 年 5 月 23 日。使用随机效应荟萃分析进行患病率汇总。
共纳入 1129 项患病率数据（28193768 名参与者）。根据考虑的定义，MetS 的全球患病率从 12.5%（95%CI：10.2-15.0）到 31.4%（29.8-33.0）不等。在东地中海地区和美洲，患病率明显较高，并且随着国家收入水平的提高而增加。特定种族中心性肥胖的全球患病率为 45.1%（95%CI：42.1-48.2），收缩压（BP）≥130mmHg 和/或舒张压（BP）≥85mmHg 的患病率为 42.6%（40.3-44.9），高密度脂蛋白胆固醇（HDL-C）<1.03 男性或<1.29mmol/L 女性的患病率为 40.2%（37.8-42.5），血清甘油三酯≥1.7mmol/L 的患病率为 28.9%（27.4-30.5），空腹血糖≥5.6mmol/L 的患病率为 24.5%（22.5-26.6）。
本研究表明，MetS 及其相关的心血管代谢成分在全球范围内高度流行。本研究呼吁采取更积极和有针对性的公共卫生干预措施来应对这些情况。
