Department of Radiology, Montefiore Medical Center, Bronx, NY, USA.
J Radiol Case Rep. 2022 Feb 1;16(2):12-20. doi: 10.3941/jrcr.v16i2.4266. eCollection 2022 Feb.
IgG4-related disease is an autoimmune condition that results in inflammation and fibrosis throughout multiple organ systems. This disease is rare; however, it can mimic many more prevalent conditions clinically and thus should be included in their differential diagnoses. Although autoimmune pancreatitis is the most common abdominal manifestation, the disease can afflict the hepatobiliary, vascular and renal systems as well. We present a case of a 78-year-old male with symptoms of chronic fatigue and weight loss. Imaging was performed with the expectation of revealing a malignancy, although the features of IgG4-related disease involving multiple organs were detected instead. Serology confirmed the diagnosis. It is imperative to diagnose IgG4-related disease early as it has a different treatment and favorable prognosis compared to many malignancies.
IgG4 相关疾病是一种自身免疫性疾病，可导致多个器官系统发生炎症和纤维化。这种疾病很少见；然而，它在临床上可能模仿许多更为常见的病症，因此应将其纳入鉴别诊断。尽管自身免疫性胰腺炎是最常见的腹部表现，但该疾病也可影响肝胆、血管和肾脏系统。我们报告了一例 78 岁男性，有慢性疲劳和体重减轻的症状。进行影像学检查是为了发现恶性肿瘤，但结果显示存在涉及多个器官的 IgG4 相关疾病特征。血清学检查证实了诊断。早期诊断 IgG4 相关疾病至关重要，因为与许多恶性肿瘤相比，它的治疗方法和预后均不同。
