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一种利用基于植物的药物发现来治愈糖尿病的疗法。

A Treatment to Cure Diabetes Using Plant-Based Drug Discovery.

作者信息

Mahankali Sumalatha, Kalava Jagadish, Garapati Yugandhar, Domathoti Bullarao, Maddumala Venkata Rao, Sundramurty Venkatesa Prabhu

机构信息

Department of Mechanical Engineering, Velagapudi Ramakrishna Siddhartha Engineering College, Vijayawada, Andhra Pradesh 520007, India.

Deaprtment of CSE, Dr.A. P. J. Abdul Kalam University, Indor, India.

出版信息

Evid Based Complement Alternat Med. 2022 May 9;2022:8621665. doi: 10.1155/2022/8621665. eCollection 2022.

DOI:10.1155/2022/8621665
PMID:35586686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9110154/
Abstract

The field of peptides and proteins has opened up new doors for plant-based medication development because of analytical breakthroughs. Enzymatic breakdown of plant-specific proteins yields bioactive peptides. These plant-based proteins and peptides, in addition to their in vitro and vivo outcomes for diabetes treatment, are discussed in this study. The secondary metabolites of vegetation can interfere with the extraction, separation, characterization, and commercialization of plant proteins through the pharmaceutical industry. Glucose-lowering diabetic peptides are a hot commodity. For a wide range of illnesses, bioactive peptides from flora can offer up new avenues for the development of cost-effective therapy options.

摘要

由于分析技术的突破,肽和蛋白质领域为基于植物的药物开发打开了新的大门。植物特异性蛋白质的酶促分解产生生物活性肽。本研究讨论了这些基于植物的蛋白质和肽,以及它们在糖尿病治疗中的体外和体内效果。植物的次生代谢产物可能会干扰制药行业对植物蛋白的提取、分离、表征和商业化。降血糖的糖尿病肽是热门商品。对于多种疾病,来自植物的生物活性肽可为开发经济高效的治疗方案提供新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad23/9110154/09a6b858db72/ECAM2022-8621665.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad23/9110154/e520dbfa61bf/ECAM2022-8621665.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad23/9110154/7add359f71c3/ECAM2022-8621665.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad23/9110154/7b845e4ca285/ECAM2022-8621665.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad23/9110154/09a6b858db72/ECAM2022-8621665.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad23/9110154/e520dbfa61bf/ECAM2022-8621665.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad23/9110154/7add359f71c3/ECAM2022-8621665.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad23/9110154/7b845e4ca285/ECAM2022-8621665.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad23/9110154/09a6b858db72/ECAM2022-8621665.004.jpg

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Biofunctional properties of bioactive peptide fractions from protein isolates of moringa seed ().辣木籽蛋白质分离物中生物活性肽组分的生物功能特性()。 注:括号部分原文缺失具体内容,所以译文括号处保留原样。
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Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial.
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The Current State of Peptide Drug Discovery: Back to the Future?肽类药物发现的现状:回到未来?
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