Evaluation of efficacy of antioxidant-enriched sunscreen prodcuts against long wavelength ultraviolet A1 and visible light.

OBJECTIVE

The synergistic effects of VL and long wavelength UVA1 (VL + UVA1, 370-700 nm) on inducing pigmentation and erythema in skin have been demonstrated and linked to exacerbation of dermatologic conditions including melasma and post-inflammatory hyperpigmentation. This study aimed to compare the photoprotection of organic sunscreens enriched with antioxidant (AO) combinations against VL + UVA1 induced biologic effects. The efficacy was compared with that offered by a commercially available tinted sunscreen.

METHODS

Ten healthy adult subjects with Fitzpatrick skin phototypes IV-VI were enrolled (nine completed). VL + UVA1 dose of 380 J/cm was utilized. Assessment methods were polarized photography, investigator global scoring and diffuse reflectance spectroscopy (DRS). Measurements were obtained at baseline and immediately, 24 h and 7 days after irradiation.

RESULTS

Sites treated with tinted sunscreen product had significantly less pigmentation compared with untreated but irradiated skin at all time points. However, DRS results demonstrated that the 5-AO sunscreen performed comparably or better than all sunscreens tested with relatively lower dyschromia, delayed erythema and pigmentation.

CONCLUSION

These results highlight the potential of AO-enriched sunscreens to be photoprotective against VL + UVA1. The combination of efficacy and the cosmetic appearance of this product may provide wider acceptability which is crucial considering the limited available means of protection against this waveband.