Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.
Department of Dermatology, Beaumont-Farmington Hills, Farmington Hills, MI, USA.
Photochem Photobiol. 2019 Nov;95(6):1285-1287. doi: 10.1111/php.13143. Epub 2019 Aug 23.
Solar radiation is known to be a major contributor to the development of skin cancer. Most sunscreen formulations, including those with broad spectrum, offer minimal protection in long-wavelength ultraviolet A1 (UVA1; 370-400 nm) and visible light (VL; 400-700 nm) domain. There is limited information regarding the impact of this broad waveband (VL + UVA1, 370-700 nm) on those with light skin. In this study, ten healthy adult subjects with Fitzpatrick skin phototypes I-III were enrolled. On day 0, subjects' lower back was exposed to a VL + UVA1 dose of 480 J cm . A statistically significant increase in erythema immediately after irradiation compared with subjects' baseline nonirradiated skin was observed. Clinically perceptible erythema with VL + UVA1 is a novel finding since the erythemogenic spectrum of sunlight has primarily been attributed to ultraviolet B and short-wavelength ultraviolet A (320-340 nm). The results emphasize the need for protection against this part of the solar spectra and warrant further investigation.
太阳辐射被认为是皮肤癌发展的一个主要因素。大多数防晒霜配方，包括那些具有广谱的配方，在长波长紫外线 A1（UVA1；370-400nm）和可见光（VL；400-700nm）区域提供最小的保护。关于这个宽波段（VL+UVA1，370-700nm）对浅色皮肤人群的影响，信息有限。在这项研究中，招募了 10 名皮肤光型 I-III 的健康成年受试者。在第 0 天，受试者的下背部接受了 480J/cm2 的 VL+UVA1 剂量。与受试者未照射皮肤的基线相比，照射后立即观察到红斑明显增加。VL+UVA1 引起的临床可察觉红斑是一个新的发现，因为阳光的致红斑光谱主要归因于紫外线 B 和短波长紫外线 A（320-340nm）。这些结果强调了需要针对太阳光谱的这一部分进行保护，并需要进一步研究。
