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使用单克隆抗体和流式细胞术检测母体外周血和子宫静脉中的合体滋养层细胞。

Detection of syncytiotrophoblast in maternal peripheral and uterine veins using a monoclonal antibody and flow cytometry.

作者信息

Kozma R, Spring J, Johnson P M, Adinolfi M

出版信息

Hum Reprod. 1986 Aug;1(5):335-6. doi: 10.1093/oxfordjournals.humrep.a136415.

DOI:10.1093/oxfordjournals.humrep.a136415
PMID:3558778
Abstract

Using a monoclonal antibody (H315) and cytofluorimetry, the presence of deported syncytiotrophoblast was investigated in blood samples collected from peripheral and uterine veins at the time of elective Caesarean sections. In all 10 women studied, a higher incidence of H315-positive syncytiotrophoblast cells was detected in the uterine samples than in peripheral blood, thus confirming that in normal pregnancies a large number of cells are shed from the placenta and gain access into the maternal circulation at the time of delivery.

摘要

利用单克隆抗体(H315)和细胞荧光测定法,在择期剖宫产时采集的外周静脉血和子宫静脉血样本中,研究了排出的合体滋养层细胞的存在情况。在所有10名研究对象中,子宫样本中检测到的H315阳性合体滋养层细胞的发生率高于外周血,从而证实,在正常妊娠中,大量细胞在分娩时从胎盘脱落并进入母体循环。

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Detection of syncytiotrophoblast in maternal peripheral and uterine veins using a monoclonal antibody and flow cytometry.使用单克隆抗体和流式细胞术检测母体外周血和子宫静脉中的合体滋养层细胞。
Hum Reprod. 1986 Aug;1(5):335-6. doi: 10.1093/oxfordjournals.humrep.a136415.
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Attempts to identify trophoblast in peripheral blood during pregnancy using monoclonal antibody H315.利用单克隆抗体H315在孕期外周血中鉴定滋养层细胞的尝试。
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