Covone A E, Mutton D, Johnson P M, Adinolfi M
Lancet. 1984 Oct 13;2(8407):841-3. doi: 10.1016/s0140-6736(84)90875-4.
The presence of human trophoblast cells in maternal blood was investigated by the use of flow cytometry and a monoclonal antibody reacting against a specific antigen present on the surface of these cells. Three types of cells derived from the placenta could be detected in the peripheral blood obtained from women between 6 weeks' gestation and term. One group of cells were polynucleated, a second group were diploid, and a third consisted of anucleate cells derived from the syncytiotrophoblast. These cells should be suitable for prenatal diagnosis of chromosomal and biochemical abnormalities.
利用流式细胞术和一种针对这些细胞表面存在的特定抗原的单克隆抗体，对母血中人类滋养层细胞的存在情况进行了研究。在妊娠6周的妇女至足月时采集的外周血中，可检测到三种源自胎盘的细胞。一组细胞是多核的，第二组是二倍体，第三组由源自合体滋养层的无核细胞组成。这些细胞应适用于染色体和生化异常的产前诊断。
