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将精准医学工具推广到 2 型糖尿病高危人群中。

Extending precision medicine tools to populations at high risk of type 2 diabetes.

机构信息

Division of Metabolism, Digestion & Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom.

Department of Diabetes, Endocrinology & Metabolism, Imperial College Healthcare NHS Trust, London, United Kingdom.

出版信息

PLoS Med. 2022 May 19;19(5):e1003989. doi: 10.1371/journal.pmed.1003989. eCollection 2022 May.

DOI:10.1371/journal.pmed.1003989
PMID:35588405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9119471/
Abstract

In this Perspective, Shivani Misra and Jose C Florez discuss the application of precision medicine tools in under-represented populations.

摘要

在这篇观点文章中,Shivani Misra 和 Jose C Florez 探讨了精准医学工具在代表性不足的人群中的应用。

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Integrating polygenic risk scores in the prediction of type 2 diabetes risk and subtypes in British Pakistanis and Bangladeshis: A population-based cohort study.将多基因风险评分整合到英国巴基斯坦裔和孟加拉裔 2 型糖尿病风险和亚型的预测中:一项基于人群的队列研究。
PLoS Med. 2022 May 19;19(5):e1003981. doi: 10.1371/journal.pmed.1003981. eCollection 2022 May.
2
Polygenic Prediction of Type 2 Diabetes in Africa.非洲 2 型糖尿病的多基因预测。
Diabetes Care. 2022 Mar 1;45(3):717-723. doi: 10.2337/dc21-0365.
3
Novel subgroups of type 2 diabetes and their association with microvascular outcomes in an Asian Indian population: a data-driven cluster analysis: the INSPIRED study.2型糖尿病的新型亚组及其与亚洲印度人群微血管结局的关联:一项数据驱动的聚类分析:INSPIRED研究
BMJ Open Diabetes Res Care. 2020 Aug;8(1). doi: 10.1136/bmjdrc-2020-001506.
4
Age-, sex- and ethnicity-related differences in body weight, blood pressure, HbA and lipid levels at the diagnosis of type 2 diabetes relative to people without diabetes.与无糖尿病患者相比,2 型糖尿病诊断时的体重、血压、HbA 和血脂水平存在年龄、性别和种族差异。
Diabetologia. 2020 Aug;63(8):1542-1553. doi: 10.1007/s00125-020-05169-6. Epub 2020 May 21.
5
Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine.用于糖尿病诊断和精准医学的遗传风险评分。
Endocr Rev. 2019 Dec 1;40(6):1500-1520. doi: 10.1210/er.2019-00088.
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Epidemiology and determinants of type 2 diabetes in south Asia.南亚 2 型糖尿病的流行病学和决定因素。
Lancet Diabetes Endocrinol. 2018 Dec;6(12):966-978. doi: 10.1016/S2213-8587(18)30204-3. Epub 2018 Oct 1.
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Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis.多特征关联提示 2 型糖尿病遗传位点指向疾病机制和亚型:软聚类分析。
PLoS Med. 2018 Sep 21;15(9):e1002654. doi: 10.1371/journal.pmed.1002654. eCollection 2018 Sep.
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Lancet Diabetes Endocrinol. 2018 May;6(5):361-369. doi: 10.1016/S2213-8587(18)30051-2. Epub 2018 Mar 5.
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