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利用遗传学推进2型糖尿病的预防。

Leveraging Genetics to Advance Type 2 Diabetes Prevention.

作者信息

Florez Jose C

机构信息

Diabetes Unit and Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

出版信息

PLoS Med. 2016 Jul 26;13(7):e1002102. doi: 10.1371/journal.pmed.1002102. eCollection 2016 Jul.

DOI:10.1371/journal.pmed.1002102
PMID:27458973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4961399/
Abstract

In this Perspective, Jose Florez discusses how information from genetics and genomics may be able to contribute to prevention of type 2 diabetes and predicting individual responses to behavioral and other interventions.

摘要

在这篇《观点》文章中，何塞·弗洛雷斯探讨了遗传学和基因组学信息如何能够有助于预防2型糖尿病以及预测个体对行为和其他干预措施的反应。

相似文献

1
Leveraging Genetics to Advance Type 2 Diabetes Prevention.利用遗传学推进2型糖尿病的预防。
PLoS Med. 2016 Jul 26;13(7):e1002102. doi: 10.1371/journal.pmed.1002102. eCollection 2016 Jul.
2
[Gene-environment interactions in the pathogenesis and prevention of type 2 diabetes mellitus].[基因-环境相互作用在2型糖尿病发病机制及预防中的作用]
Internist (Berl). 2007 Jul;48(7):669-70, 672, 674-5. doi: 10.1007/s00108-007-1874-1.
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Assessing diabetes risk: danger in the family tree.评估糖尿病风险：家族中的危险因素
Adv Nurse Pract. 2006 Mar;14(3):55-6.
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Metabolic complications of visceral obesity: contribution to the aetiology of type 2 diabetes and implications for prevention and treatment.内脏肥胖的代谢并发症：对2型糖尿病病因的作用及对预防和治疗的意义
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Pharmacologic approaches to the prevention of type 2 diabetes in high risk pediatric patients.高危儿科患者2型糖尿病预防的药理学方法。
J Clin Endocrinol Metab. 2003 Jan;88(1):3-13. doi: 10.1210/jc.2002-021033.
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[Genetic background of diabetes mellitus type 2].[2型糖尿病的遗传背景]
Ned Tijdschr Geneeskd. 2009;153:A959.
7
Sound the alarm. Childhood obesity and the emergence of type 2 diabetes.敲响警钟。儿童肥胖与2型糖尿病的出现。
Adv Nurse Pract. 2005 Aug;13(8):37-40, 42.
8
Exercise, genetics and prevention of type 2 diabetes.运动、遗传与2型糖尿病的预防
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Focus on obesity.关注肥胖问题。
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Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects.2型糖尿病中的基因-环境与基因-治疗相互作用：进展、困境与前景
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Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation.糖尿病多基因风险评分：异质性与临床转化。
Nat Rev Endocrinol. 2025 Jun 4. doi: 10.1038/s41574-025-01132-w.
2
Genetics of type 2 diabetes mellitus in Indian and Global Population: A Review.印度和全球人群2型糖尿病的遗传学：综述
Egypt J Med Hum Genet. 2022;23(1):135. doi: 10.1186/s43042-022-00346-1. Epub 2022 Sep 2.
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The contribution of common and rare genetic variants to variation in metabolic traits in 288,137 East Asians.28.8137 万东亚人中常见和罕见遗传变异对代谢特征变化的贡献。

本文引用的文献

1
Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants.生活方式和二甲双胍可独立于糖尿病预防计划参与者中已确定的胰岛素抵抗变异体的遗传负担来改善胰岛素敏感性。
Diabetes. 2016 Feb;65(2):520-6. doi: 10.2337/db15-0950. Epub 2015 Nov 2.
2
Genetic Predisposition to Weight Loss and Regain With Lifestyle Intervention: Analyses From the Diabetes Prevention Program and the Look AHEAD Randomized Controlled Trials.生活方式干预导致体重减轻及反弹的遗传易感性：糖尿病预防计划和“展望”随机对照试验的分析
Diabetes. 2015 Dec;64(12):4312-21. doi: 10.2337/db15-0441. Epub 2015 Aug 7.
3
Nat Commun. 2022 Nov 4;13(1):6642. doi: 10.1038/s41467-022-34163-2.
4
Cardiovascular Risk Factors and Physical Activity for the Prevention of Cardiovascular Diseases in the Elderly.老年人心血管疾病的心血管危险因素和身体活动预防。
Int J Environ Res Public Health. 2021 Dec 25;19(1):207. doi: 10.3390/ijerph19010207.
5
Pure additive contribution of genetic variants to a risk prediction model using propensity score matching: application to type 2 diabetes.使用倾向得分匹配法，基因变异对风险预测模型的纯加性贡献：在2型糖尿病中的应用
Genomics Inform. 2019 Dec;17(4):e47. doi: 10.5808/GI.2019.17.4.e47. Epub 2019 Dec 23.
6
Influence of obesity, parental history of diabetes, and genes in type 2 diabetes: A case-control study.2 型糖尿病中肥胖、父母糖尿病史和基因的影响：一项病例对照研究。
Sci Rep. 2019 Feb 26;9(1):2748. doi: 10.1038/s41598-019-39145-x.
7
Precision medicine in diabetes: an opportunity for clinical translation.糖尿病精准医学：临床转化的机遇。
Ann N Y Acad Sci. 2018 Jan;1411(1):140-152. doi: 10.1111/nyas.13588.
8
A Decade of Genetic and Metabolomic Contributions to Type 2 Diabetes Risk Prediction.十年间遗传和代谢组学对2型糖尿病风险预测的贡献
Curr Diab Rep. 2017 Nov 4;17(12):135. doi: 10.1007/s11892-017-0958-0.
9
Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells.内质网应激和 eIF2α 磷酸化：胰腺 β 细胞的阿喀琉斯之踵。
Mol Metab. 2017 Jul 12;6(9):1024-1039. doi: 10.1016/j.molmet.2017.06.001. eCollection 2017 Sep.
10
Prediction of gene expression with cis-SNPs using mixed models and regularization methods.使用混合模型和正则化方法通过顺式单核苷酸多态性预测基因表达
BMC Genomics. 2017 May 11;18(1):368. doi: 10.1186/s12864-017-3759-6.
Recent advances in understanding the genetic architecture of type 2 diabetes.
2型糖尿病遗传结构认识的最新进展
Hum Mol Genet. 2015 Oct 15;24(R1):R85-92. doi: 10.1093/hmg/ddv264. Epub 2015 Jul 9.
4
A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes.常见的格陵兰 TBC1D4 变异导致肌肉胰岛素抵抗和 2 型糖尿病。
Nature. 2014 Aug 14;512(7513):190-3. doi: 10.1038/nature13425. Epub 2014 Jun 18.
5
Metabolite traits and genetic risk provide complementary information for the prediction of future type 2 diabetes.代谢物特征和遗传风险为预测未来2型糖尿病提供了互补信息。
Diabetes Care. 2014 Sep;37(9):2508-14. doi: 10.2337/dc14-0560. Epub 2014 Jun 19.
6
Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population.拉丁裔人群中HNF1A基因低频变异与2型糖尿病的关联
JAMA. 2014 Jun 11;311(22):2305-14. doi: 10.1001/jama.2014.6511.
7
Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study.基因-生活方式相互作用与 2 型糖尿病：EPIC 相互作用病例-队列研究。
PLoS Med. 2014 May 20;11(5):e1001647. doi: 10.1371/journal.pmed.1001647. eCollection 2014 May.
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Lancet Diabetes Endocrinol. 2014 Jun;2(6):474-80. doi: 10.1016/S2213-8587(14)70057-9. Epub 2014 Apr 3.
9
Polygenic type 2 diabetes prediction at the limit of common variant detection.多基因 2 型糖尿病在常见变异检测极限下的预测。
Diabetes. 2014 Jun;63(6):2172-82. doi: 10.2337/db13-1663. Epub 2014 Feb 11.
10
Effectiveness and cost-effectiveness of diabetes prevention among adherent participants.糖尿病预防依从者的效果和成本效益。
Am J Manag Care. 2013;19(3):194-202.