Department of Medicinal Chemistry, Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou 563000, China; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563000, China.
Department of Cell Biology, Zunyi Medical University, Zunyi 563000, China.
Fitoterapia. 2022 Jul;160:105220. doi: 10.1016/j.fitote.2022.105220. Epub 2022 May 16.
Four previously undescribed compounds, including three glucosyloxybenzyl 2-isobutylmalates (1-3), one phenolic glycoside (4), along with ten known compounds were isolated from the flowers of Bletilla striata. The structures and absolute configurations of the undescribed compounds were elucidated on the basis of HR-ESIMS, NMR spectroscopy, optical rotation value, and acid hydrolysis experiment. Cytotoxicity of the isolated compounds against A549, HCT-116, and SW1990 cells and protective effects of t-BHP-induced L02 cytotoxic were assayed. The antioxidant activities of the isolated compounds were also evaluated.
从白及花中分离得到四个以前未描述的化合物，包括三个葡萄糖氧基苄基 2-异丁基马来酸酯（1-3），一个酚糖苷（4），以及十个已知化合物。在 HR-ESIMS、NMR 光谱、旋光度和酸水解实验的基础上，阐明了未描述化合物的结构和绝对构型。测定了分离化合物对 A549、HCT-116 和 SW1990 细胞的细胞毒性以及 t-BHP 诱导的 L02 细胞毒性的保护作用。还评估了分离化合物的抗氧化活性。
