从白芨假鳞茎中分离得到的神经保护新木脂素糖苷。
Neuroprotective neolignan glycosides from the pseudobulbs of Bletilla striata.
机构信息
Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, People's Republic of China.
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
出版信息
Fitoterapia. 2023 Dec;171:105691. doi: 10.1016/j.fitote.2023.105691. Epub 2023 Sep 26.
Four undescribed neolignan glycosides, bletineosides A-D (1-4) were isolated from the pseudobulbs of Bletilla striata. Their structures with absolute configurations were elucidated on the basis of spectroscopic analyses, along with acidic hydrolysis reactions and ECD experiments. All isolates were evaluated for their neuroprotective activities against glutamate-induced PC12 cell injury. Compound 3 and 4 showed significantly neuroprotective effects at the concentration of 10 μM when compared with the model group. Compounds 1-4 represented the first examples of neolignan glycosides from the genus Bletilla. This study disclosed the potency of Bletilla striata as a new source of anti-neurodegenerative agents.
从白及假鳞茎中分离得到 4 个新的木脂素糖苷，分别命名为 bletineosides A-D（1-4）。基于光谱分析，并结合酸水解反应和 ECD 实验，确定了它们的结构及其绝对构型。所有分离得到的化合物都进行了神经保护活性评价，以评估其对谷氨酸诱导的 PC12 细胞损伤的抑制作用。与模型组相比，化合物 3 和 4 在 10 μM 浓度下表现出显著的神经保护作用。化合物 1-4 代表了白及属中木脂素糖苷的首例。本研究揭示了白及作为新型神经退行性疾病治疗药物的潜力。
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