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剖宫产术后阴道播种:我们能否构建更好的婴儿微生物组?

Vaginal seeding after cesarean birth: Can we build a better infant microbiome?

机构信息

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Department of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

出版信息

Med. 2021 Aug 13;2(8):889-891. doi: 10.1016/j.medj.2021.07.003.

DOI:10.1016/j.medj.2021.07.003
PMID:35590163
Abstract

In this issue of Med, Song et al. compared 174 maternal and 177 infant microbiota after vaginal and cesarean delivery, including 30 vaginally seeded cesarean-born infants. Vaginal seeding partially corrected the microbial divergence observed between cesarean- and vaginal-born infant microbiomes. Infant microbiota resembled corresponding maternal sites, despite delivery mode or seeding.

摘要

在本期 Med 杂志上,Song 等人比较了 174 名阴道分娩和 177 名剖宫产产妇及其婴儿的微生物组,其中包括 30 名经阴道分娩的剖宫产婴儿。阴道定植部分纠正了剖宫产和阴道分娩婴儿微生物组之间观察到的微生物差异。尽管分娩方式或定植情况不同,婴儿的微生物组仍与相应的母体部位相似。

相似文献

1
Vaginal seeding after cesarean birth: Can we build a better infant microbiome?剖宫产术后阴道播种:我们能否构建更好的婴儿微生物组?
Med. 2021 Aug 13;2(8):889-891. doi: 10.1016/j.medj.2021.07.003.
2
Oral administration of maternal vaginal microbes at birth to restore gut microbiome development in infants born by caesarean section: A pilot randomised placebo-controlled trial.出生时经口摄入母体阴道微生物以恢复剖宫产婴儿肠道微生物组发育:一项先导随机安慰剂对照试验。
EBioMedicine. 2021 Jul;69:103443. doi: 10.1016/j.ebiom.2021.103443. Epub 2021 Jun 27.
3
Maternal Bacterial Engraftment in Multiple Body Sites of Cesarean Section Born Neonates after Vaginal Seeding-a Randomized Controlled Trial.剖宫产儿阴道定植后多个部位的母婴细菌定植:一项随机对照试验。
mBio. 2023 Jun 27;14(3):e0049123. doi: 10.1128/mbio.00491-23. Epub 2023 Apr 19.
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Effects of vaginal seeding on gut microbiota, body mass index, and allergy risks in infants born through cesarean delivery: a randomized clinical trial.剖宫产婴儿阴道定植对肠道微生物群、体重指数和过敏风险的影响:一项随机临床试验。
Am J Obstet Gynecol MFM. 2023 Jan;5(1):100793. doi: 10.1016/j.ajogmf.2022.100793. Epub 2022 Nov 2.
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Naturalization of the microbiota developmental trajectory of Cesarean-born neonates after vaginal seeding.阴道播种后剖宫产出生新生儿微生物群发育轨迹的本土化。
Med. 2021 Aug 13;2(8):951-964.e5. doi: 10.1016/j.medj.2021.05.003. Epub 2021 Jun 17.
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Maternal bacteria to correct abnormal gut microbiota in babies born by C-section.母体细菌可纠正剖宫产出生婴儿的肠道微生物群异常。
Medicine (Baltimore). 2020 Jul 24;99(30):e21315. doi: 10.1097/MD.0000000000021315.
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Does vaginal delivery mitigate or strengthen the intergenerational association of overweight and obesity? Findings from the Boston Birth Cohort.阴道分娩会减轻还是强化超重与肥胖的代际关联?来自波士顿出生队列的研究结果。
Int J Obes (Lond). 2017 Apr;41(4):497-501. doi: 10.1038/ijo.2016.219. Epub 2016 Nov 30.
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Birth Mode Does Not Determine the Presence of Shared Bacterial Strains between the Maternal Vaginal Microbiome and the Infant Stool Microbiome.分娩方式并不会决定母婴阴道微生物群和婴儿粪便微生物群之间的细菌菌株共享。
Microbiol Spectr. 2023 Aug 17;11(4):e0061423. doi: 10.1128/spectrum.00614-23. Epub 2023 Jun 20.
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Effects of vaginal microbiota transfer on the neurodevelopment and microbiome of cesarean-born infants: A blinded randomized controlled trial.阴道微生物群转移对剖宫产婴儿神经发育和微生物组的影响:一项盲法随机对照试验。
Cell Host Microbe. 2023 Jul 12;31(7):1232-1247.e5. doi: 10.1016/j.chom.2023.05.022. Epub 2023 Jun 15.
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Maternal Fecal Microbiota Transplantation in Cesarean-Born Infants Rapidly Restores Normal Gut Microbial Development: A Proof-of-Concept Study.剖宫产儿的母体粪便微生物移植可快速恢复正常肠道微生物发育:概念验证研究。
Cell. 2020 Oct 15;183(2):324-334.e5. doi: 10.1016/j.cell.2020.08.047. Epub 2020 Oct 1.

引用本文的文献

1
Crucial nuances in understanding (mis)associations between the neonatal microbiome and Cesarean delivery.理解新生儿微生物组与剖宫产之间(错误)关联的关键细微差别。
Trends Mol Med. 2022 Oct;28(10):806-822. doi: 10.1016/j.molmed.2022.07.005. Epub 2022 Sep 6.