Myrelid Pär, Soop Mattias, George Bruce D
Department of Surgery, Linköping University Hospital and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Department of Surgery, Ersta Hospital, Karolinska Institutet at Danderyd Hospital, Stockholm, Sweden.
Front Surg. 2022 May 3;9:867830. doi: 10.3389/fsurg.2022.867830. eCollection 2022.
Crohn's disease (CD) is increasing globally, and the disease location and behavior are changing toward more colonic as well as inflammatory behavior. Surgery was previously mainly performed due to ileal/ileocaecal location and stricturing behavior, why many anticipate the surgical load to decrease. There are, however, the same time data showing an increasing complexity among patients at the time of surgery with an increasing number of patients with the abdominal perforating disease, induced by the disease itself, at the time of surgery and thus a more complex surgery as well as the post-operative outcome. The other major cause of abdominal penetrating CD is secondary to surgical complications, e.g., anastomotic dehiscence or inadvertent enterotomies. To improve the care for patients with penetrating abdominal CD in general, and in the peri-operative phase in particular, the use of multidisciplinary team discussions is essential. In this study, we will try to give an overview of penetrating abdominal CD today and how this situation may be handled. Proper surgical planning will decrease the risk of surgically induced penetrating disease and improve the outcome when penetrating disease is already established. It is important to evaluate patients prior to surgery and optimize them with enteral nutrition (or parenteral if enteral nutrition is ineffective) and treat abdominal sepsis with drainage and antibiotics.
克罗恩病(CD)在全球范围内呈上升趋势,其病变部位和行为正朝着更多累及结肠以及炎症性表现发展。以往手术主要因病变位于回肠/回盲部以及狭窄性病变而进行,因此许多人预计手术量会减少。然而,与此同时的数据显示,手术时患者情况日益复杂,手术时因疾病本身导致腹部穿孔性疾病的患者数量增加,从而使手术更为复杂,术后结果也更难预料。腹部穿透性CD的另一个主要原因是手术并发症,例如吻合口裂开或意外肠切开。为了总体上改善对腹部穿透性CD患者的护理,尤其是围手术期护理,多学科团队讨论的应用至关重要。在本研究中,我们将试图概述当今腹部穿透性CD的情况以及如何应对这种情况。恰当的手术规划将降低手术诱发穿透性疾病的风险,并在穿透性疾病已经存在时改善治疗结果。术前评估患者并通过肠内营养(若肠内营养无效则采用肠外营养)使其状况优化,以及通过引流和使用抗生素治疗腹部脓毒症,这些都很重要。