在 ……中基因、毒力及相关调控机制。
Gene, virulence and related regulatory mechanisms in .
机构信息
Department of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University; Peking University Ninth School of Clinical Medicine, Beijing 100089, China.
Department of Laboratory Medicine, the First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China.
出版信息
Acta Biochim Biophys Sin (Shanghai). 2022 May 25;54(5):593-603. doi: 10.3724/abbs.2022029.
is a kind of basidiomycetous yeast, which grows in human and animal hosts. . has four distinct genomes, VGI/AFLP4, VGII/AFLP6, VGIII/AFLP5, and VGIV/AFLP7. The virulence of . is closely associated with genotype and related stress-signaling pathways, but the pathogenic mechanism of . has not been fully identified. With the development of genomics and transcriptomics, the relationship among genes, regulatory mechanisms, virulence, and treatment is gradually being recognized. In this review, to better understand how . causes disease and to characterize hypervirulent . strains, we summarize the current understanding of . genotypes, phenotypes, virulence, and the regulatory mechanisms.
是一种担子菌酵母，生长在人类和动物宿主中。它有四个不同的基因组，VGIAFLP4、VGIIAFLP6、VGIIIAFLP5 和 VGIVAFLP7。的毒力与基因型和相关应激信号通路密切相关，但的致病机制尚未完全确定。随着基因组学和转录组学的发展，基因、调控机制、毒力和治疗之间的关系逐渐被认识。在这篇综述中，为了更好地了解如何引起疾病，并描述超强毒力的菌株，我们总结了目前对基因型、表型、毒力和调控机制的理解。
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