《前沿进展：从实验室到临床及其他》中的新内容
What's New in : From Bench to Bedside and Beyond.
作者信息
Beardsley Justin, Dao Aiken, Keighley Caitlin, Garnham Katherine, Halliday Catriona, Chen Sharon C-A, Sorrell Tania C
机构信息
Sydney Infectious Disease Institute, University of Sydney, Sydney, NSW 2145, Australia.
Westmead Hospital, New South Wales Health, Sydney, NSW 2145, Australia.
出版信息
J Fungi (Basel). 2022 Dec 27;9(1):41. doi: 10.3390/jof9010041.
species are a major cause of life-threatening infections in immunocompromised and immunocompetent hosts. While most disease is caused by , , a genotypically and phenotypically distinct species, is responsible for 11-33% of global cases of cryptococcosis. Despite best treatment, infections are associated with early mortality rates of 10-25%. The World Health Organization's recently released Fungal Priority Pathogen List classified as a medium-priority pathogen due to the lack of effective therapies and robust clinical and epidemiological data. This narrative review summarizes the latest research on the taxonomy, epidemiology, pathogenesis, laboratory testing, and management of infections.
该物种是免疫功能低下和免疫功能正常宿主中危及生命感染的主要原因。虽然大多数疾病是由 、 引起的，但 是一种在基因型和表型上都不同的物种，占全球隐球菌病病例的11%-33%。尽管进行了最佳治疗，但 感染的早期死亡率仍为10%-25%。由于缺乏有效的治疗方法以及可靠的临床和流行病学数据，世界卫生组织最近发布的真菌重点病原体清单将 列为中等优先级病原体。这篇叙述性综述总结了关于 感染的分类学、流行病学、发病机制、实验室检测和管理的最新研究。
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