Department of Neurology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 West Five Road, Xi'an, Shaanxi, China.
Department of Neurology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 West Five Road, Xi'an, Shaanxi, China.
J Clin Neurosci. 2022 Jul;101:118-123. doi: 10.1016/j.jocn.2022.05.011. Epub 2022 May 17.
Microalbuminuria (MAU) reflects the generalized vascular endothelial dysfunction. Whether MAU has correlation with atherosclerotic intracranial and extracranial arterial stenosis in cerebral infarction patients is not known and is explored in the present investigation.
We enrolled 255 cerebral infarction patients hospitalized at the department of neurology. All patients underwent digital subtraction angiography (DSA) to evaluate the severity and distribution of intracranial and extracranial arterial stenosis. MAU was expressed as the urine albumin-to-creatinine ratio (UACR). We collected basic information, medical history reviews and laboratory results of each participant. The multivariate logistic regression analysis was utilized to analyze the risk factors for severity and distribution of cerebral arterial stenosis.
The prevalence of MAU in patients with cerebral infarction was 39.2%, patients with MAU had older age, lower blood uric acid, higher systolic blood pressure (SBP), higher prevalence of hypertension and diabetes (p < 0.05) and higher incidence of atherosclerotic intracranial and extracranial arterial stenosis (χ2 = 5.900, p = 0.015). In multiple logistic regression analysis for intracranial and extracranial arterial stenosis more than 50% or occlusion groups, UACR (OR 1.088 95%CI 1.012-1.170p = 0.022), male (OR 2.196 95%CI 1.085-4.442p = 0.029) as well as SBP (OR 5.870 95%CI 1.026-1.048p = 0.015) showed statistical significance. But UACR had no correlation with the distribution of intracranial and extracranial artery stenosis after adjusting for all potential confounders.
Microalbuminuria was an independent risk factor for intracranial and extracranial arterial stenosis more than 50% or occlusion.
微量白蛋白尿（MAU）反映了全身性血管内皮功能障碍。MAU 是否与脑梗死患者的动脉粥样硬化性颅内和颅外动脉狭窄有关尚不清楚，本研究对此进行了探讨。
我们纳入了 255 例神经内科住院的脑梗死患者。所有患者均行数字减影血管造影（DSA）评估颅内和颅外动脉狭窄的严重程度和分布情况。MAU 用尿白蛋白/肌酐比值（UACR）表示。收集每位参与者的基本信息、病史回顾和实验室结果。采用多变量 logistic 回归分析来分析脑动脉狭窄严重程度和分布的危险因素。
脑梗死患者 MAU 的患病率为 39.2%，患有 MAU 的患者年龄较大，血尿酸较低，收缩压（SBP）较高，高血压和糖尿病的患病率较高（p<0.05），且动脉粥样硬化性颅内和颅外动脉狭窄的发生率较高（χ2=5.900，p=0.015）。在颅内和颅外动脉狭窄超过 50%或闭塞组的多变量 logistic 回归分析中，UACR（OR 1.088，95%CI 1.012-1.170，p=0.022）、男性（OR 2.196，95%CI 1.085-4.442，p=0.029）以及 SBP（OR 5.870，95%CI 1.026-1.048，p=0.015）均有统计学意义。但是在校正了所有潜在混杂因素后，UACR 与颅内和颅外动脉狭窄的分布没有相关性。
微量白蛋白尿是颅内和颅外动脉狭窄超过 50%或闭塞的独立危险因素。
