甲磺酸溴隐亭对非哺乳期妇女乳腺分泌物成分的影响。

Effects of bromocriptine mesylate on the composition of the mammary secretion in non-breast-feeding women.

作者信息

Kulski J K, Hartmann P E, Martin J D, Smith M

出版信息

Obstet Gynecol. 1978 Jul;52(1):38-42.

Abstract

A double-blind trial was performed on 26 women, who had elected not to breast-feed their infants, to determine the effect of bromocriptine mesylate (2.5 mg twice daily for 14 days postpartum) on the composition of the mammary secretion during lactogenesis. Mammary secretion (less than 5.0 ml) was collected from each breast of each woman at daily intervals during the 14-day treatment period and the progressive changes in the concentration of the milk constituents, lactose, alpha-lactalbumin, serum albumin, total protein, lactoferin, IgA, IgG, sodium and potassium were determined. The degree of milk leakage and breast engorgement were also assessed. Both the subjective assessments and the changes in the concentration of the milk constituents demonstrated that lactogenesis occurred between about Day 2 and Day 5 postpartum in the placebo group (in the absence of the suckling stimulus) but was suppressed in the bromocriptine-treated group.

摘要

对26名选择不母乳喂养婴儿的女性进行了一项双盲试验，以确定甲磺酸溴隐亭（产后14天每天两次，每次2.5毫克）对泌乳期乳腺分泌物成分的影响。在为期14天的治疗期间，每天从每位女性的每个乳房收集乳腺分泌物（少于5.0毫升），并测定乳汁成分、乳糖、α-乳白蛋白、血清白蛋白、总蛋白、乳铁蛋白、IgA、IgG、钠和钾浓度的逐步变化。还评估了乳汁漏出和乳房胀痛的程度。主观评估和乳汁成分浓度变化均表明，安慰剂组（在没有哺乳刺激的情况下）在产后约第2天至第5天发生泌乳，但在溴隐亭治疗组中受到抑制。