Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Pediatric Translational Medicine Institute, Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Autism Dev Disord. 2023 Aug;53(8):2954-2963. doi: 10.1007/s10803-022-05603-1. Epub 2022 May 20.
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder that brings heavy burdens to families and the society. This case-control study explored risk factors for ASD based on 74,252 children aged 3-12 years who were recruited from general education kindergartens, primary schools, and special education schools in Shanghai, China. One hundred ninety-two children were identified with ASD according to the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition. Male sex, the presence of anoxia or asphyxia at birth, artificial feeding, adverse maternal psychological status, complications during pregnancy and higher paternal education were associated with ASD even after controlling for age, residential district, family history of mental disorders, parental personality, and amount of daily TV viewing.
自闭症谱系障碍（ASD）是一种普遍存在的神经发育障碍，给家庭和社会带来沉重负担。本病例对照研究基于来自中国上海普通教育幼儿园、小学和特殊教育学校的 74252 名 3-12 岁儿童，探讨了 ASD 的危险因素。根据《精神障碍诊断与统计手册第五版》，确定了 192 名患有 ASD 的儿童。即使在控制了年龄、居住区域、精神障碍家族史、父母个性和每日看电视时间等因素后，男性、出生时缺氧或窒息、人工喂养、母亲心理状况不良、妊娠并发症和父亲教育程度较高与 ASD 仍相关。
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