Seetho Kellie, Zhang Shiyi, Pollack Kevin A, Zou Jiong, Raymond Jeffery E, Martinez Edgar, Wooley Karen L
Departments of Chemistry, Chemical Engineering and Materials Science and Engineering, Laboratory for Synthetic-Biologic Interactions, Texas A&M University, College Station, Texas 77842, United States.
Beckman Coulter Particle Characterization Laboratory, MS 22-B02, Miami, Florida 33196, United States.
ACS Macro Lett. 2015 May 19;4(5):505-510. doi: 10.1021/mz500818c. Epub 2015 Apr 17.
An antibiofouling polymer coating, combined with both zwitterionic and amphiphilic features, is engineered by a two-step modification of a commodity polymer. The surface properties of the resultant polymer coating can be easily tuned by varying the extent of cross-linking in the network. Higher antibiofouling efficiency was observed for these surfaces vs. an elastomeric polydimethylsiloxane standard (Sylgard 184) against the adsorption of biomacromolecules and a marine fouling organism ( zoospores) has been demonstrated. This design establishes a platform for the achievement of functionalized amphiphilic zwitterionic copolymers from relatively inexpensive starting materials via simple chemical manipulations.
一种兼具两性离子和两亲性特征的抗生物污损聚合物涂层，是通过对一种商用聚合物进行两步改性而设计出来的。所得聚合物涂层的表面性质可通过改变网络中的交联程度轻松调节。与弹性聚二甲基硅氧烷标准品（Sylgard 184）相比，这些表面在抑制生物大分子吸附方面表现出更高的抗生物污损效率，并且已证明对一种海洋污损生物（游动孢子）具有抗性。这种设计通过简单的化学操作，从相对廉价的起始材料出发，建立了一个实现功能化两亲性两性离子共聚物的平台。
