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本文引用的文献

1
Facile Synthesis of a Phosphorylcholine-Based Zwitterionic Amphiphilic Copolymer for Anti-Biofouling Coatings.用于抗生物污损涂层的基于磷酰胆碱的两性离子两亲共聚物的简便合成
ACS Macro Lett. 2015 May 19;4(5):505-510. doi: 10.1021/mz500818c. Epub 2015 Apr 17.
2
Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.在具有免疫活性的小鼠中使用聚合物封装的人干细胞衍生的β细胞进行长期血糖控制。
Nat Med. 2016 Mar;22(3):306-11. doi: 10.1038/nm.4030. Epub 2016 Jan 25.
3
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates.组合水凝胶文库有助于识别减轻灵长类动物体内异物反应的材料。
Nat Biotechnol. 2016 Mar;34(3):345-52. doi: 10.1038/nbt.3462. Epub 2016 Jan 25.
4
A survey of state-of-the-art surface chemistries to minimize fouling from human and animal biofluids.研究最先进的表面化学方法以最小化人体和动物生物流体的污染。
Biomater Sci. 2015 Oct 15;3(10):1335-70. doi: 10.1039/c5bm00085h. Epub 2015 Jul 27.
5
Quantitative Characterization of Collagen in the Fibrotic Capsule Surrounding Implanted Polymeric Microparticles through Second Harmonic Generation Imaging.通过二次谐波产生成像对植入聚合物微粒周围纤维化包膜中的胶原蛋白进行定量表征。
PLoS One. 2015 Jun 30;10(6):e0130386. doi: 10.1371/journal.pone.0130386. eCollection 2015.
6
Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates.植入啮齿动物和非人灵长类动物体内的材料的尺寸和形状依赖性异物免疫反应。
Nat Mater. 2015 Jun;14(6):643-51. doi: 10.1038/nmat4290. Epub 2015 May 18.
7
Cytoprotective alginate/polydopamine core/shell microcapsules in microbial encapsulation.在微生物包封中具有细胞保护作用的藻酸盐/聚多巴胺核/壳微胶囊。
Angew Chem Int Ed Engl. 2014 Dec 22;53(52):14443-6. doi: 10.1002/anie.201408454. Epub 2014 Oct 29.
8
Reduction of the inflammatory responses against alginate-poly-L-lysine microcapsules by anti-biofouling surfaces of PEG-b-PLL diblock copolymers.聚乙二醇-聚-L-赖氨酸二嵌段共聚物的抗生物污染表面降低对海藻酸钠-聚-L-赖氨酸微胶囊的炎症反应
PLoS One. 2014 Oct 27;9(10):e109837. doi: 10.1371/journal.pone.0109837. eCollection 2014.
9
Brush-like polycarbonates containing dopamine, cations, and PEG providing a broad-spectrum, antibacterial, and antifouling surface via one-step coating.通过一步涂覆，含有多巴胺、阳离子和 PEG 的刷状聚碳酸酯提供了广谱抗菌和抗污表面。
Adv Mater. 2014 Nov 19;26(43):7346-51. doi: 10.1002/adma.201402059. Epub 2014 Sep 10.
10
Engineering biomaterials surfaces to modulate the host response.设计生物材料表面以调节宿主反应。
Colloids Surf B Biointerfaces. 2014 Dec 1;124:69-79. doi: 10.1016/j.colsurfb.2014.08.009. Epub 2014 Aug 20.

一种赋予生物材料装置两性离子表面涂层的简便通用方法。

A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings.

作者信息

Yesilyurt Volkan, Veiseh Omid, Doloff Joshua C, Li Jie, Bose Suman, Xie Xi, Bader Andrew R, Chen Michael, Webber Matthew J, Vegas Arturo J, Langer Robert, Anderson Daniel G

机构信息

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.

出版信息

Adv Healthc Mater. 2017 Feb;6(4). doi: 10.1002/adhm.201601091. Epub 2016 Dec 15.

DOI:10.1002/adhm.201601091
PMID:27976536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5322155/
Abstract

The surface modification of implantable biomaterials with zwitterionic phosphorylcholine polymer is demonstrated through mussel-mimetic catecholamine polymer thin films. Using this method, the surfaces of alginate hydrogel microspheres and polystyrene microbeads, a model material known to produce robust foreign body responses and fibrosis, are successfully modified to reduce the tissue reaction by reducing the fibrosis in immunocompetent C57BL/6J mice.

摘要

通过模仿贻贝的儿茶酚胺聚合物薄膜，展示了用两性离子磷酸胆碱聚合物对可植入生物材料进行表面改性。使用这种方法，藻酸盐水凝胶微球和聚苯乙烯微珠（一种已知会产生强烈异物反应和纤维化的模型材料）的表面被成功改性，以通过减少免疫活性C57BL/6J小鼠的纤维化来降低组织反应。