一种赋予生物材料装置两性离子表面涂层的简便通用方法。
A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings.
作者信息
Yesilyurt Volkan, Veiseh Omid, Doloff Joshua C, Li Jie, Bose Suman, Xie Xi, Bader Andrew R, Chen Michael, Webber Matthew J, Vegas Arturo J, Langer Robert, Anderson Daniel G
机构信息
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.
出版信息
Adv Healthc Mater. 2017 Feb;6(4). doi: 10.1002/adhm.201601091. Epub 2016 Dec 15.
Abstract
The surface modification of implantable biomaterials with zwitterionic phosphorylcholine polymer is demonstrated through mussel-mimetic catecholamine polymer thin films. Using this method, the surfaces of alginate hydrogel microspheres and polystyrene microbeads, a model material known to produce robust foreign body responses and fibrosis, are successfully modified to reduce the tissue reaction by reducing the fibrosis in immunocompetent C57BL/6J mice.
摘要
通过模仿贻贝的儿茶酚胺聚合物薄膜，展示了用两性离子磷酸胆碱聚合物对可植入生物材料进行表面改性。使用这种方法，藻酸盐水凝胶微球和聚苯乙烯微珠（一种已知会产生强烈异物反应和纤维化的模型材料）的表面被成功改性，以通过减少免疫活性C57BL/6J小鼠的纤维化来降低组织反应。
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