Louarn F, Gray F, Gaston A, Gherardi R, Keohane C, Degos J D
J Neurol. 1987 Feb;234(2):107-11. doi: 10.1007/BF00314113.
A case is reported of the rare association between progressive multifocal leucoencephalopathy and carcinoma. A 66-year-old man underwent a laryngectomy for carcinoma. Four years later he developed a local recurrence. Simultaneously there were behavioural disturbances and a left motor neglect followed by dense hemiplegia and coma. The patient died a further 5 months later. Anergy was demonstrated by skin tests. CT scan showed asymmetrical non-enhancing low-density areas in the hemispheric white matter, brain-stem and cerebellum and neuropathological examination confirmed extensive myelin loss with typical papovavirus inclusions in oligodendrocytes identified by electron microscopy.
报告了一例进行性多灶性白质脑病与癌症罕见关联的病例。一名66岁男性因癌症接受了喉切除术。四年后出现局部复发。同时出现行为障碍和左侧运动忽视，随后发展为严重偏瘫和昏迷。患者在5个月后死亡。皮肤试验显示无反应性。CT扫描显示半球白质、脑干和小脑有不对称的无强化低密度区，神经病理学检查证实广泛的髓鞘脱失，电子显微镜检查在少突胶质细胞中发现典型的乳头多瘤空泡病毒包涵体。
