纳米狭缝中DNA的力-伸长：三维与二维极限之间的映射

Force-Extension for DNA in a Nanoslit: Mapping between the 3D and 2D Limits.

作者信息

de Haan Hendrick W, Shendruk Tyler N

机构信息

University of Ontario Institute of Technology, Faculty of Science, 2000 Simcoe Street North, Oshawa, Ontario L1H 7K4, Canada.

The Rudolf Peierls Centre for Theoretical Physics, Department of Physics, Theoretical Physics, University of Oxford, 1 Keble Road, Oxford, OX1 3NP, United Kingdom.

出版信息

ACS Macro Lett. 2015 Jun 16;4(6):632-635. doi: 10.1021/acsmacrolett.5b00138. Epub 2015 May 20.

DOI:10.1021/acsmacrolett.5b00138

PMID:35596406

Abstract

The force-extension relation for a semiflexible polymer confined in a nanoslit is investigated. Both the effective correlation length and force-extension relation change as the chain goes from 3D (large slit heights) to 2D (tight confinement). At low forces, correlations along the polymer give an effective dimensionality. The strong force limit can be interpolated with the weak force limit for two regimes: when confinement dominates over extensile force and vice versa. These interpolations give good agreement with simulations for all slit heights and forces. We thus generalize the Marko-Siggia force-extension relation for DNA and other semiflexible biopolymers in nanoconfinement.

摘要

研究了限制在纳米狭缝中的半柔性聚合物的力-伸长关系。当链从三维（大狭缝高度）转变为二维（紧密限制）时，有效相关长度和力-伸长关系都会发生变化。在低力情况下，聚合物上的相关性给出了一个有效的维度。对于两种情况，强力极限可以与弱力极限进行插值：当限制作用超过拉伸力时，反之亦然。这些插值结果与所有狭缝高度和力的模拟结果吻合良好。因此，我们推广了纳米限制条件下DNA和其他半柔性生物聚合物的马尔科-西吉亚力-伸长关系。