Yeow Jonathan, Xu Jiangtao, Boyer Cyrille
Centre for Advanced Macromolecular Design (CAMD) and Australian Centre for NanoMedicine (ACN), School of Chemical Engineering, UNSW Australia, Sydney, NSW 2052, Australia.
ACS Macro Lett. 2015 Sep 15;4(9):984-990. doi: 10.1021/acsmacrolett.5b00523. Epub 2015 Aug 27.
The ruthenium-based photoredox catalyst, Ru(bpy)Cl, was employed to activate reversible addition-fragmentation chain transfer (RAFT) dispersion polymerization via a photoinduced electron transfer (PET) process under visible light (λ = 460 nm, 0.7 mW/cm). Poly(oligo(ethylene glycol) methyl ether methacrylate) was chain extended with benzyl methacrylate to afford in situ self-assembled polymeric nanoparticles with various morphologies. The effect of different intrinsic reaction parameters, such as catalyst concentration, total solids content, and cosolvent addition was investigated with respect to the formation of different nanoparticle morphologies, including spherical micelles, worm-like micelles, and vesicles. Importantly, highly pure worm-like micelles were readily isolated due to the in situ formation of highly viscous gels. Finally, "ON/OFF" control over the dispersion polymerization was demonstrated by online Fourier transform near-infrared (FTNIR) spectroscopy, allowing for temporal control over the nanoparticle morphology.
钌基光氧化还原催化剂Ru(bpy)Cl用于在可见光（λ = 460 nm，0.7 mW/cm）下通过光诱导电子转移（PET）过程激活可逆加成-断裂链转移（RAFT）分散聚合。聚（聚乙二醇甲基醚甲基丙烯酸酯）与甲基丙烯酸苄酯进行链增长反应，以原位自组装得到具有各种形态的聚合物纳米颗粒。研究了不同固有反应参数，如催化剂浓度、总固体含量和助溶剂添加量对不同纳米颗粒形态形成的影响，包括球形胶束、蠕虫状胶束和囊泡。重要的是，由于原位形成高粘性凝胶，可轻松分离出高纯度的蠕虫状胶束。最后，通过在线傅里叶变换近红外（FTNIR）光谱证明了对分散聚合的“开/关”控制，从而实现对纳米颗粒形态的时间控制。
