College of Health and Life Sciences, Hamad bin Khalifa University, Qatar Foundation, P.O. Box 34110, Doha, Qatar; Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, P.O. Box 34110, Doha, Qatar.
Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, P.O. Box 34110, Doha, Qatar.
Neurobiol Dis. 2022 Aug;170:105771. doi: 10.1016/j.nbd.2022.105771. Epub 2022 May 19.
Despite the increasing number of studies on Parkinson's disease and it being the second most common neurodegenerative disorder in the world, no established diagnostic markers or disease modifying therapies are available. Understanding the mechanisms involved in its pathogenesis and identifying markers capable of diagnosing or tracking progression of PD is greatly needed. Among the several factors identified to be involved in Parkinson's disease, the immune system has had increasingly growing evidence that presents a fresh avenue to investigate the pathology of the disease. The involvement of the immune system in the pathology of Parkinson's disease has been linked to an interaction between the peripheral and central nervous system immune response. Whether this involvement is due to an immune response being a cause or consequence of Parkinson's disease pathology is still a matter of debate. Players investigated include cytokines, chemokines, and immune-cells found in both the central and peripheral immune system. Herein, we discuss advances in the current literature on these immune-related markers and their potential use as markers for Parkinson's disease diagnosis and progression.
尽管越来越多的研究关注帕金森病，且它是世界上第二常见的神经退行性疾病，但目前尚无明确的诊断标志物或可改变疾病进程的治疗方法。因此，我们非常需要了解其发病机制中的相关机制，并确定能够诊断或跟踪 PD 进展的标志物。在已确定的几种与帕金森病相关的因素中，免疫系统的证据越来越多，为研究疾病的病理学提供了新的途径。免疫系统在帕金森病病理学中的作用与外周和中枢神经系统免疫反应之间的相互作用有关。这种参与是由于免疫反应是帕金森病病理学的原因还是后果，仍存在争议。研究人员调查了包括细胞因子、趋化因子和存在于中枢和外周免疫系统中的免疫细胞等因素。本文讨论了当前关于这些免疫相关标志物的文献进展，以及它们作为帕金森病诊断和进展标志物的潜在用途。
