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聚四氟乙烯所致职业性肺部疾病。

Occupational Lung Disease Caused by Exposure to Polytetrafluoroethylene.

机构信息

Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Department of Respiratory Medicine, Saiseikai Niigata Hospital, Japan.

出版信息

Intern Med. 2022 Dec 15;61(24):3713-3717. doi: 10.2169/internalmedicine.9008-21. Epub 2022 May 21.

DOI:10.2169/internalmedicine.9008-21
PMID:35598992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9841090/
Abstract

We herein report a 45-year-old-man with multiple foreign body granulomas in the lungs caused by polytetrafluoroethylene (PTFE). A mass in the right lower lobe of the lung and bilateral centrilobular lung nodules were found unexpectedly during the patient's visit to a hospital for a respiratory infection. The patient's occupation for 26 years involved spraying PTFE. A lung biopsy using bronchoscopy revealed granulomatous lesions and giant cells. The presence of fluorine in the granulomatous lesions was confirmed using an electron probe microanalyzer with wavelength dispersive spectrometer. Fluorine is a component of PTFE and is not found in normal lung tissue.

摘要

我们在此报告一例 45 岁男性，因聚四氟乙烯（PTFE）引起肺部多发异物性肉芽肿。患者因呼吸道感染就诊时意外发现右下肺肿块和双侧小叶中心性肺结节。患者 26 年的职业涉及喷涂 PTFE。经支气管镜肺活检显示肉芽肿性病变和多核巨细胞。电子探针微分析仪结合波谱仪证实了肉芽肿病变中氟的存在。氟是 PTFE 的成分，在正常肺组织中不存在。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4838/9841090/034eaadeceae/1349-7235-61-3713-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4838/9841090/4d19091dec2c/1349-7235-61-3713-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4838/9841090/87641a45699b/1349-7235-61-3713-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4838/9841090/530dc852f292/1349-7235-61-3713-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4838/9841090/034eaadeceae/1349-7235-61-3713-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4838/9841090/4d19091dec2c/1349-7235-61-3713-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4838/9841090/87641a45699b/1349-7235-61-3713-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4838/9841090/530dc852f292/1349-7235-61-3713-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4838/9841090/034eaadeceae/1349-7235-61-3713-g004.jpg

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Occupational Lung Disease Caused by Exposure to Polytetrafluoroethylene.聚四氟乙烯所致职业性肺部疾病。
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本文引用的文献

1
Pneumoconiosis in a polytetrafluoroethylene (PTFE) spray worker: a case report with an occupational hygiene study.一名聚四氟乙烯（PTFE）喷涂工人的尘肺病：一份伴有职业卫生研究的病例报告
Ann Occup Environ Med. 2018 Jun 4;30:37. doi: 10.1186/s40557-018-0248-6. eCollection 2018.
2
Small airway-centered granulomatosis caused by long-term exposure to polytetrafluoroethylene.长期接触聚四氟乙烯所致的以小气道为中心的肉芽肿病
Chest. 2014 Jun;145(6):1397-1402. doi: 10.1378/chest.13-1997.
3
Elemental analysis of occupational and environmental lung diseases by electron probe microanalyzer with wavelength dispersive spectrometer.
采用带有波长色散光谱仪的电子探针微分析仪对职业性和环境性肺部疾病进行元素分析。
Respir Investig. 2014 Jan;52(1):5-13. doi: 10.1016/j.resinv.2013.05.002. Epub 2013 Jul 5.
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Surgical pathology of non-neoplastic lung disease.
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