Cui Shuyue, Tang Shuai, Ding Xiaoling, Ding Gang
School of Stomatology, Weifang Medical University, Weifang 261053, China.
Zhongguo Fei Ai Za Zhi. 2022 May 20;25(5):351-357. doi: 10.3779/j.issn.1009-3419.2022.101.20.
In China, malignant tumor is the main cause of death in both urban and rural areas. Mesenchymal stem cells (MSCs) have multidirectional differentiation potential, self-renewal ability and good immunomodulatory properties. Exosomes, as important paracrine substances of MSCs, mediate information exchange and transmission between cells in tumor microenvironment and influence the occurrence and development of tumors. Recently, conflicting findings have been reported on the effects of MSCs and their exosomes on tumors. On the one hand, MSCs and their exosomes are tumorigenic and can target specific sites to inhibit tumor growth; On the other hand, there is also evidence that MSCs could affect tumor growth and migration as part of the tumor microenvironment. In this paper, we will review the relationship between MSCs and exosomes and tumorgenesis and development, as well as how MSCs and exosomes play different roles in tumorgenesis and development, in order to provide beneficial help for tumor diagnosis, prognosis and precise treatment. .
在中国，恶性肿瘤是城乡地区的主要死因。间充质干细胞（MSCs）具有多向分化潜能、自我更新能力和良好的免疫调节特性。外泌体作为MSCs重要的旁分泌物质，介导肿瘤微环境中细胞间的信息交流与传递，影响肿瘤的发生发展。近年来，关于MSCs及其外泌体对肿瘤的影响报道结果相互矛盾。一方面，MSCs及其外泌体具有致瘤性，可靶向特定部位抑制肿瘤生长；另一方面，也有证据表明MSCs作为肿瘤微环境的一部分可影响肿瘤生长和迁移。在本文中，我们将综述MSCs和外泌体与肿瘤发生发展的关系，以及MSCs和外泌体在肿瘤发生发展过程中如何发挥不同作用，以期为肿瘤诊断、预后及精准治疗提供有益帮助。
