Zhao Rou, Chen Xinke, Song Hui, Bie Qingli, Zhang Bin
Department of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
Department of Microbiology, Qingdao University Life Science College, Qingdao, Shandong, China.
Stem Cells Int. 2020 Sep 9;2020:8844730. doi: 10.1155/2020/8844730. eCollection 2020.
Mesenchymal stem cells (MSCs) are a class of adult stem cells derived from the mesoderm. They can self-renew, have multidirectional differentiation potential, and can differentiate into a variety of mesenchymal tissues. MSCs can produce a large number of exosomes, which can mediate information exchange and transmission between cells in the tumor microenvironment under conditions of rest or stress. Recent studies have reported conflicting findings regarding the effect of MSC-derived exosomes on tumors. Some studies have suggested that MSC-derived exosomes can promote tumor growth and metastasis, but others have reported that they can inhibit tumor cell growth. Here, we investigate the two sides of the debate regarding the effect of MSC-derived exosomes on tumors and analyze the reasons for the divergent findings.
间充质干细胞（MSCs）是一类源自中胚层的成体干细胞。它们能够自我更新，具有多向分化潜能，并可分化为多种间充质组织。间充质干细胞能产生大量外泌体，在静止或应激条件下，这些外泌体可介导肿瘤微环境中细胞间的信息交换与传递。近期研究报道了关于间充质干细胞来源的外泌体对肿瘤影响的相互矛盾的结果。一些研究表明，间充质干细胞来源的外泌体可促进肿瘤生长和转移，但另一些研究则报道它们能抑制肿瘤细胞生长。在此，我们探讨关于间充质干细胞来源的外泌体对肿瘤影响这一争论的双方观点，并分析结果分歧的原因。
