地球生物基因组计划：现状与未来规划。

Earth Biogenome Project: present status and future plans.

作者信息

Gupta Pushpendra Kumar

机构信息

Department of Genetics and Plant Breeding, Ch. Charan Singh University, Meerut, India 250004, India; Murdoch's Centre for Crop & Food Innovation, Murdoch University, Murdoch, WA 6150, Australia.

出版信息

Trends Genet. 2022 Aug;38(8):811-820. doi: 10.1016/j.tig.2022.04.008. Epub 2022 May 19.

DOI:10.1016/j.tig.2022.04.008

PMID:35599020

Abstract

Earth Biogenome Project (EBP) is an ambitious project targeted to provide high-quality reference genome sequences for all 1.8 million named extant (living) eukaryote species. The project was launched on 1 November 2018 with an initial 2 years' pilot phase (2018-2020) followed by Phase I (2020-2023), during which genomes of 9400 species will be sequenced. The genomes of the remaining ~1.7 million species will be sequenced in a planned manner during Phase II (2024-2027) and Phase III (2028-2030). In view of the excitement generated and the progress already made, the subject was covered in a Special Feature of a recent issue of PNAS (25 January 2022). The present status and future plans of EBP along with challenges faced are briefly discussed in this article.

摘要

地球生物基因组计划（EBP）是一项雄心勃勃的计划，旨在为所有180万个已知的现存（活着的）真核生物物种提供高质量的参考基因组序列。该计划于2018年11月1日启动，最初为期2年的试点阶段（2018 - 2020年），随后是第一阶段（2020 - 2023年），在此期间将对9400个物种的基因组进行测序。其余约170万个物种的基因组将在第二阶段（2024 - 2027年）和第三阶段（2028 - 2030年）按计划进行测序。鉴于该计划所引发的兴奋之情以及已经取得的进展，近期一期《美国国家科学院院刊》（2022年1月25日）的一个专题对此进行了报道。本文简要讨论了EBP的现状、未来计划以及所面临的挑战。