Department of Pharmacology and Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA, Selangor, Malaysia.
Clin Breast Cancer. 2022 Aug;22(6):499-506. doi: 10.1016/j.clbc.2022.04.006. Epub 2022 Apr 26.
RUNX1 has long known for its role in hematopoiesis until recently it is implicated in human breast cancer pathogenesis. This has drawn attention in research as elevated expression of RUNX1 has been observed in invasive breast cancer, and mutations of the RUNX1 gene and its binding partner CBFβ have been identified in luminal breast cancer patients, many of which have attributed to the development and progression of the disease. Increasing number of evidence also shows the involvement of RUNX1 in breast cancer migration and invasion that may lead to breast cancer metastasis. However, more studies need to be conducted to better understand its roles in these particular subtypes in breast cancer. This is important as evidence so far indicates that there are discrepancies with regards to the roles of RUNX1 in ER-positive and ER-negative breast cancer, both of which have posted a great challenge to recognize whether its deregulation is protecting or promoting breast cancer. This warrants further analysis to glean more information especially considering the perturbation of RUNX1 is mainly reported in ER-positive breast cancer. In this review, the roles of RUNX1 in breast cancer are discussed in a context dependent manner based on its involvement in the development and progression of the disease. The association of RUNX1 with other types of cancer is also included to emphasize a wider and possibly a different angle of involvement of RUNX1 in cancer.
RUNX1 长期以来一直因其在造血中的作用而为人所知，直到最近，它才被牵涉到人类乳腺癌的发病机制中。这引起了研究人员的关注，因为在浸润性乳腺癌中观察到 RUNX1 的表达升高，并且在腔乳腺癌患者中已经鉴定出 RUNX1 基因及其结合伴侣 CBFβ的突变，其中许多突变归因于疾病的发展和进展。越来越多的证据还表明 RUNX1 参与乳腺癌的迁移和侵袭，这可能导致乳腺癌转移。然而，还需要更多的研究来更好地理解它在乳腺癌这些特定亚型中的作用。这很重要，因为到目前为止的证据表明，RUNX1 在 ER 阳性和 ER 阴性乳腺癌中的作用存在差异，这两者都对识别其失调是保护还是促进乳腺癌提出了巨大挑战。这需要进一步分析以获取更多信息，特别是考虑到 RUNX1 的失调主要在 ER 阳性乳腺癌中报道。在这篇综述中，根据 RUNX1 参与疾病的发展和进展，以依赖于上下文的方式讨论了 RUNX1 在乳腺癌中的作用。还包括了 RUNX1 与其他类型癌症的关联，以强调 RUNX1 可能在癌症中涉及更广泛和可能不同的角度。
