School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, New South Wales, Australia.
Centre for Active Living and Learning, The University of Newcastle, Callaghan, New South Wales, Australia.
Psychophysiology. 2022 Nov;59(11):e14090. doi: 10.1111/psyp.14090. Epub 2022 May 22.
Although well-evidenced in older adults, the effects of exercise on the hippocampus in youth are relatively unknown. This study examined the impact of a 6-month school-based physical activity intervention on hippocampal metabolism in adolescents using magnetic resonance spectroscopy. A subset of lower fit older adolescents [N = 56, 61% female, 16.1 ± 0.4 years] was included from four secondary schools (10 classes) in New South Wales, Australia, who were participating in a larger cluster randomized controlled trial. Participants were randomized to the Burn 2 Learn (B2L) intervention (five classes, 30 participants) or a control group (five classes, 26 participants). Changes in hippocampal metabolism were assessed using linear mixed models adjusted for clustering at the class level. We observed group-by-time effects for the B2L intervention on N-acetylaspartate (NAA) (+2.66 mmol/L, 95% CI 0.20 to 5.11, d = 0.66) and glutamate+glutamine (Glx) (+3.38 mmol/L, 95% CI 0.34 to 6.42, d = 0.67) in the left hippocampus. Increases in left hippocampal NAA and Glx concentrations were associated with improvements in cardiorespiratory fitness (NAA: r = 0.52, p = .016; Glx: r = 0.57, p = .007), lower body muscular fitness (NAA: r = 0.49, p = .018; Glx: r = 0.59, p = .003), and working memory (NAA: r = 0.42, p = .032; Glx: r = 0.43, p = .028) in the intervention group. Our findings suggest physical activity may improve hippocampal metabolism in lower fit older adolescents with implications for working memory. Further studies involving larger samples are needed to replicate our findings.
虽然在老年人中得到了很好的证明，但运动对年轻人海马体的影响相对未知。本研究使用磁共振波谱检查了一项为期 6 个月的基于学校的体育活动干预对青少年海马代谢的影响。从澳大利亚新南威尔士州的四所中学（10 个班）中选取了一部分较低适应能力的青少年（N=56，女性占 61%，16.1±0.4 岁），他们参加了一项更大的集群随机对照试验。参与者被随机分配到 Burn 2 Learn（B2L）干预组（5 个班，30 名参与者）或对照组（5 个班，26 名参与者）。使用线性混合模型调整班级水平的聚类，评估了海马代谢的变化。我们观察到 B2L 干预对左侧海马体 N-乙酰天冬氨酸（NAA）（+2.66mmol/L，95%置信区间 0.20 至 5.11，d=0.66）和谷氨酸+谷氨酰胺（Glx）（+3.38mmol/L，95%置信区间 0.34 至 6.42，d=0.67）的组间时间效应。左侧海马体 NAA 和 Glx 浓度的增加与心肺适能（NAA：r=0.52，p=0.016；Glx：r=0.57，p=0.007）、下肢肌肉适能（NAA：r=0.49，p=0.018；Glx：r=0.59，p=0.003）和工作记忆（NAA：r=0.42，p=0.032；Glx：r=0.43，p=0.028）的改善相关在干预组中。我们的发现表明，体育活动可能会改善适应能力较低的青少年的海马代谢，这对工作记忆有影响。需要更大样本的进一步研究来复制我们的发现。
