Theoretical Biology Research Group, Budapest, Hungary.
Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, Bari, Italy.
FEBS Lett. 2022 Aug;596(15):1955-1968. doi: 10.1002/1873-3468.14408. Epub 2022 Jun 9.
Glycolysis is present in nearly all organisms alive today. This article proposes an evolutionary trajectory for the development of glycolysis in the framework of the chemoautotrophic theory for the origin of life. In the proposal, trioses and triose-phosphates were appointed to starting points. The six-carbon and the three-carbon intermediates developed in the direction of gluconeogenesis and glycolysis, respectively, differing from the from-bottom-to-up development of enzymatic glycolysis. The examination of enzymatic reaction mechanisms revealed that the enzymes incorporated chemical mechanisms of the nonenzymatic stage, making possible to identify kinship between glyoxalases and glyceraldehyde 3-phosphate dehydrogenase as well as methylglyoxal synthase and triose-phosphate isomerase. This developmental trajectory may shed light on how glycolysis might have developed in the nonenzymatic era.
糖酵解几乎存在于当今所有生物中。本文在生命起源的化能自养理论框架内，提出了糖酵解在进化过程中的发展轨迹。在该提议中，指定了丙糖和丙糖磷酸作为起点。六碳和三碳中间产物分别朝着糖异生和糖酵解的方向发展，与酶促糖酵解的自下而上的发展不同。对酶促反应机制的研究表明，这些酶结合了非酶促阶段的化学机制，使醛缩酶和甘油醛-3-磷酸脱氢酶以及甲基乙二醛合酶和磷酸丙糖异构酶之间存在亲缘关系成为可能。这种发展轨迹可能揭示了糖酵解在非酶促时代是如何发展的。
