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2021年基于机构的前瞻性单臂队列研究:脊髓麻醉下剖宫产术后硬膜外穿刺头痛的发生率及相关因素

Incidence and associated factors of post dural puncture headache in cesarean section done under spinal anesthesia 2021 institutional based prospective single-armed cohort study.

作者信息

Girma Timsel, Mergia Getachew, Tadesse Muhiddin, Assen Sofia

机构信息

Department of Anesthesiology, Dilla University, Dilla, Ethiopia.

Department of Obstetrics and Gynaecology, Dilla University, Dilla, Ethiopia.

出版信息

Ann Med Surg (Lond). 2022 May 7;78:103729. doi: 10.1016/j.amsu.2022.103729. eCollection 2022 Jun.

Abstract

BACKGROUND

Spinal anesthesia is the most commonly used anesthesia technique for Cesarean delivery with 80%-95% prevalence. The most common complication of SA is post-dural puncture Headache which is associated with dural puncture & Cerebrospinal fluid leak. This study aimed to assess the incidence and associated factors of post-dural puncture headache.

METHODS

single-armed cohort study design was employed on 412 women from May 2021 to January 2022. Study subjects were selected using systematic random sampling. Descriptive statistics for each variable, binary logistic regression, and multiple logistic regression analysis with 95% CI was carried out.

RESULTS

The overall incidence of post-dural puncture headache in this study was 25.7%. 43.9% of Post dural headache was detected in the 1st 24 h followed by 48 h. Of those who develop Post-dural headaches, 54.1% of them had mild pain, 17.3% of them was moderate pain and 28.6% of them suffered severe pain. The multivariable analysis indicated that BMI>30 kg/m [AOR 2.85 95% CI: 1.91-4.25], number of attempts (>3), (AOR = 1.5, 95% CI: 1.19-1.91), and cephalic needle direction (AOR = 5.79 95% CI: 2.27-12.22), were factors associated with increased post-dural puncture headache. While large gauge needle size (AOR = 0.28 95% CI: 0.19-0.42), and greater than 3 years of experience of anesthetist (AOR = 0.44, 95% CI: 0.31-0.62) were associated with decreased incidence of post-dural puncture headache.

CONCLUSION

The incidence of post-dural puncture headache was higher in BMI>30 kg/m, greater than 3-time attempts during spinal anesthesia, using low gauge spinal needles, less than 3 years of experience as anesthetist and cephalic needle direction.

摘要

背景

脊髓麻醉是剖宫产最常用的麻醉技术,使用率为80%-95%。脊髓麻醉最常见的并发症是腰穿后头痛,其与硬脊膜穿刺和脑脊液漏有关。本研究旨在评估腰穿后头痛的发生率及相关因素。

方法

2021年5月至2022年1月,对412名女性采用单臂队列研究设计。研究对象采用系统随机抽样法选取。对每个变量进行描述性统计、二元逻辑回归分析以及95%置信区间的多元逻辑回归分析。

结果

本研究中腰穿后头痛的总体发生率为25.7%。43.9%的腰穿后头痛在最初24小时内被检测到,其次是48小时内。在发生腰穿后头痛的患者中,54.1%为轻度疼痛,17.3%为中度疼痛,28.6%为重度疼痛。多变量分析表明,体重指数>30kg/m²(调整后比值比[AOR]=2.85,95%置信区间:1.91-4.25)、穿刺次数>3次(AOR=1.5,95%置信区间:1.19-1.91)以及头端针方向(AOR=5.79,95%置信区间:2.27-12.22)是与腰穿后头痛发生率增加相关的因素。而大号穿刺针(AOR=0.28,95%置信区间:0.19-0.42)以及麻醉医生经验超过3年(AOR=0.44,95%置信区间:0.31-0.62)与腰穿后头痛发生率降低相关。

结论

体重指数>30kg/m²、脊髓麻醉时穿刺次数超过3次、使用小号脊髓穿刺针、麻醉医生经验不足3年以及头端针方向与腰穿后头痛的发生率较高有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4946/9121279/cfe1704303bf/gr1.jpg

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