Tadesse Tesfaye Yimer, Molla Mulugeta, Yimer Yohannis Shumet, Tarekegn Benyas Shishigie, Kefale Belayneh
Pharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Pharmaceutics and Social Pharmacy Unit, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
SAGE Open Med. 2022 May 14;10:20503121221096608. doi: 10.1177/20503121221096608. eCollection 2022.
Even though antibiotic resistance is one of the most serious threats to global public health, it is becoming more common due to inappropriate antibiotic prescribing patterns. Thus, the purpose of this study is to assess antibiotic prescribing patterns among inpatients at an Ethiopian comprehensive specialized hospital.
An institutional-based cross-sectional study was used. During the study period, data were collected from the charts of admitted patients in selected wards of Debre Tabor comprehensive specialized hospital. The World Health Organization's developed questionnaire and conventional antibiotic prescribing indicators were used to assess rational drug usage, with an emphasis on antibiotic prescribing trends. The data were analyzed using SPSS 25.0 statistical software.
For 861 patients admitted to medical and pediatric wards, a total of 1444 antibiotics were prescribed. Overall, 60.6% of inpatients were prescribed at least one antibiotic, with an average (mean ± SD) number of antibiotics prescribed per patient of 1.7 ± 1.6. During their hospital stay, patients were given antibiotics for an average (mean ± SD) of 6.4 ± 2.7 days. Furthermore, 83.3% of antibiotics were prescribed for therapeutic purposes, whereas 100% were provided for empiric purposes. Ceftriaxone was the most commonly administered antibiotic in the study settings (49.2%). During the study period, Debre Tabor comprehensive specialized hospital had access to 67.5% of key antibiotics.
The antibiotic prescribing pattern in our study diverged from the World Health Organization-recommended guidelines. Furthermore, all antibiotics were given without a culture or sensitivity test in every case. Setting up an antibiotic stewardship program, introducing antibiotic use based on culture and sensitivity tests, and adopting institutional guidelines could all help to address this issue.
尽管抗生素耐药性是对全球公共卫生最严重的威胁之一，但由于不恰当的抗生素处方模式，其正变得越来越普遍。因此，本研究的目的是评估埃塞俄比亚一家综合专科医院住院患者的抗生素处方模式。
采用基于机构的横断面研究。在研究期间，从德布雷塔博尔综合专科医院选定病房的住院患者病历中收集数据。使用世界卫生组织制定的问卷和传统的抗生素处方指标来评估合理用药情况，重点是抗生素处方趋势。使用SPSS 25.0统计软件对数据进行分析。
对于入住内科和儿科病房的861名患者，共开出了1444剂抗生素。总体而言，60.6%的住院患者至少开具了一种抗生素，每位患者开具的抗生素平均（均值±标准差）数量为1.7±1.6剂。在住院期间，患者接受抗生素治疗的平均（均值±标准差）天数为6.4±2.7天。此外，83.3%的抗生素是用于治疗目的，而100%是用于经验性治疗。头孢曲松是研究环境中最常用的抗生素（49.2%）。在研究期间，德布雷塔博尔综合专科医院能够获取67.5%的关键抗生素。
我们研究中的抗生素处方模式与世界卫生组织推荐的指南不同。此外，所有病例在未进行培养或药敏试验的情况下就使用了抗生素。建立抗生素管理计划、引入基于培养和药敏试验的抗生素使用方法以及采用机构指南都有助于解决这一问题。
