Nawzad Sina, Cahn Wiepke, Abdullah-Koolmees Heshu
Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands.
Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
Ther Adv Psychopharmacol. 2022 May 16;12:20451253221097452. doi: 10.1177/20451253221097452. eCollection 2022.
Patients with dementia often suffer from behavioral changes. A common behavioral change is acute physical aggressive behavior which is the most distressing change. This can lead to harm, which is especially problematic in nursing homes. Despite the serious safety concerns, antipsychotics are often prescribed to combat this problem. This article is aimed to review the evidence of the efficacy of utilizing antipsychotics in acutely treating physical aggressive behavior in patients with dementia in nursing homes. Therefore, a systematic literature search was performed. The results demonstrated that a meta-analysis confirmed statistically significant reduction in physical aggression when risperidone was compared to placebo. However, a randomized controlled trial showed no change in physical aggressive behavior between quetiapine and placebo. More research is needed to fully investigate the benefits of physical aggressive behavior and safety concerns of all the antipsychotics in patients with dementia in nursing homes.
患有痴呆症的患者经常会出现行为变化。一种常见的行为变化是急性身体攻击性行为，这是最令人痛苦的变化。这可能会导致伤害，在养老院中这一问题尤为突出。尽管存在严重的安全隐患，但抗精神病药物常被用于解决这一问题。本文旨在综述在养老院中使用抗精神病药物急性治疗痴呆症患者身体攻击性行为的疗效证据。因此，进行了系统的文献检索。结果表明，一项荟萃分析证实，与安慰剂相比，利培酮在统计学上能显著减少身体攻击行为。然而，一项随机对照试验显示，喹硫平和安慰剂之间在身体攻击行为方面没有变化。需要更多的研究来全面调查养老院中痴呆症患者身体攻击行为的益处以及所有抗精神病药物的安全隐患。
