Blankenship Jennifer M, Vetter Céline, Broussard Josiane L
Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Department of Integrative Physiology, University of Colorado, Boulder, CO, USA.
Sleep Adv. 2022 Apr 19;3(1):zpac009. doi: 10.1093/sleepadvances/zpac009. eCollection 2022.
Repeated bouts of circadian misalignment impair glucose tolerance. However, whether circadian misalignment associated with travel and jet lag impair glucose homeostasis in a free-living population is not known. The goal of the present study was to examine glycemic control during one week of Eastbound transatlantic travel in healthy men and women.
Seven healthy participants (5 women; age: 35.6 ± 2.5 years, BMI: 23.9 ± 2.4 m/kg) traveled from Colorado, USA (GMT-7) to Europe (GMT and GMT+1) and wore a continuous glucose monitor (Freestyle Libre Pro) for 8-14 days before, during, and after travel. Indices of glycemic control were summarized over 24-hour periods and by day and night.
Mean glucose, peak glucose, and time spent in hyperglycemia increased linearly throughout the travel period relative to baseline levels. Mean glucose concentrations rose 1.03 mg/dL (95% CI: 0.34, 1.74) and duration of hyperglycemia increased by 17 min (95% CI: 5.5, 28.6) each 24-hour period. Increases in 24-hour glucose were primarily driven by increases in daytime parameters with rising mean glucose (0.72 mg/dL per day, [95% CI: -0.1, 1.5]) and duration of hyperglycemia (13.2 min per day [95% CI: 4.3, 22.1]). Mean glucose, but not peak glucose or time spent in hyperglycemia, increased each night (0.7 mg/dL per night [95% CI: 0.2, 1.2]).
Eastbound transatlantic travel induced a progressive worsening of glucose metrics during 24-hour, day, and night periods. Future research on managing glycemic control during jet lag in people with metabolic disorders is warranted.
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反复的昼夜节律失调会损害葡萄糖耐量。然而，与旅行和时差相关的昼夜节律失调是否会损害自由生活人群的葡萄糖稳态尚不清楚。本研究的目的是在健康男性和女性进行为期一周的跨大西洋东行旅行期间，检查血糖控制情况。
7名健康参与者（5名女性；年龄：35.6±2.5岁，体重指数：23.9±2.4 m/kg）从美国科罗拉多州（格林威治标准时间-7）前往欧洲（格林威治标准时间和格林威治标准时间+1），并在旅行前、旅行期间和旅行后佩戴连续血糖监测仪（Freestyle Libre Pro）8-14天。血糖控制指标按24小时时间段以及白天和夜间进行汇总。
相对于基线水平，整个旅行期间平均血糖、血糖峰值和高血糖持续时间呈线性增加。每24小时平均血糖浓度上升1.03 mg/dL（95%置信区间：0.34，1.74），高血糖持续时间增加17分钟（95%置信区间：5.5，28.6）。24小时血糖的升高主要由白天参数的增加驱动平均血糖升高（每天0.72 mg/dL，[95%置信区间：-0.1，1.5]）和高血糖持续时间增加（每天13.2分钟[95%置信区间：4.3，22.1]）。平均血糖每晚升高（每晚0.7 mg/dL [95%置信区间：0.2，1.2]），但血糖峰值或高血糖持续时间未升高。
跨大西洋东行旅行导致24小时、白天和夜间时间段的血糖指标逐渐恶化。有必要对代谢紊乱患者在时差期间的血糖控制管理进行进一步研究。
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