Bannister P, Mortimer A, Shapiro L, Simms A C
J R Soc Med. 1987 Feb;80(2):77-8. doi: 10.1177/014107688708000206.
A thyroid function screening programme of admissions to a general psychiatric service was established. Over a 22-week period 588 patients were admitted and thyroid function tests were performed on 336, a screening rate of 57.1%. Initial investigation showed that 21.3% had a total thyroxine outside the range 75-130 nmol/l. On further investigation only 9 patients (1 thyrotoxic, 8 hypothyroid) had confirmed thyroid disease. In 7 of the 9 patients the disease had been clinically suspected. Thus the screening programme identified only 2 unsuspected cases of thyroid dysfunction and we conclude that this level of detection does not warrant a formal screening programme.
建立了一项针对综合精神科服务入院患者的甲状腺功能筛查计划。在22周的时间里,共有588名患者入院,其中336名进行了甲状腺功能测试,筛查率为57.1%。初步调查显示,21.3%的患者总甲状腺素水平超出75 - 130 nmol/l的范围。进一步调查发现,只有9名患者(1名甲状腺毒症患者,8名甲状腺功能减退患者)被确诊患有甲状腺疾病。在这9名患者中,有7名临床上已怀疑患有该病。因此,该筛查计划仅发现了2例未被怀疑的甲状腺功能障碍病例,我们得出结论,这种检测水平不值得开展正式的筛查计划。