King G C, Goldson A L, Galal F, Ashayeri E
J Natl Med Assoc. 1987 Feb;79(2):189-92.
The preliminary experience of the use of a prototype hyperthermia unit (Astro 200) for tumor regression in Howard University Hospital's Department of Radiotherapy is described. The purpose of this study was to produce homogeneous heat distribution patterns within a 5-cm cylinder in the middle of a phantom (ground beef) using radio frequency conducted through electrodes implanted in the medium. Homogeneous heat distribution was achieved by finding the optimal spatial distribution of electrodes within the phantom and by sequencing the radio frequency in the electrodes. Monitored observation revealed a steady state homogeneous temperature of 42.5 °C within a 4-cm diameter. There was a temperature difference of 0.5 °C within 1 cm of the periphery.Heat in the clinical range of 42 to 43 °C has caused tumor regression, and was found to be most effective when combined with another modality of radiation. At Howard University Hospital, hyperthermia is used in conjunction with conventional modalities-surgery, radiotherapy, and chemotherapy-in the treatment of tumors.
描述了在霍华德大学医院放疗科使用原型热疗设备（Astro 200）实现肿瘤消退的初步经验。本研究的目的是通过植入介质中的电极传导射频，在体模（碎牛肉）中部的一个5厘米圆柱体内部产生均匀的热分布模式。通过找到电极在体模内的最佳空间分布并对电极中的射频进行排序，实现了均匀的热分布。监测观察显示，在直径4厘米范围内温度稳定且均匀，为42.5°C。在外围1厘米范围内温度差为0.5°C。42至43°C临床范围内的热已导致肿瘤消退，并且发现与另一种放射治疗方式联合使用时最为有效。在霍华德大学医院，热疗与传统治疗方式——手术、放疗和化疗——联合用于治疗肿瘤。
