黏蛋白的作用与功能及其与炎症性肠病的关系
The Role and Function of Mucins and Its Relationship to Inflammatory Bowel Disease.
作者信息
Kang Youra, Park Hyeonjeong, Choe Byung-Ho, Kang Ben
机构信息
Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea.
Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, South Korea.
出版信息
Front Med (Lausanne). 2022 May 6;9:848344. doi: 10.3389/fmed.2022.848344. eCollection 2022.
Mucus is present throughout the gastrointestinal tract and is essential for regulating gut microbiota homeostasis and preventing disease by protecting the gastrointestinal barrier from microorganisms, pathogens and toxins or other irritants. Mucin (MUC)-2 is a secreted protein produced by epithelial goblet cells as the main component of mucus. Defects in the gastrointestinal tract, such as inflammation and ulcers, cause damage to the mucus barrier, which can worsen mucus quality and reduce mucus production. Therefore, we would like to review the characteristics of MUC2 and its role in intestinal disorders and highlight the importance of further studies. We also investigated whether the role of MUC2 differs between children and adults, ulcerative colitis (UC) and Crohn's disease (CD).
黏液存在于整个胃肠道，对于调节肠道微生物群稳态以及通过保护胃肠道屏障免受微生物、病原体、毒素或其他刺激物的侵害来预防疾病至关重要。黏蛋白（MUC）-2是上皮杯状细胞分泌的一种蛋白质，是黏液的主要成分。胃肠道的缺陷，如炎症和溃疡，会导致黏液屏障受损，进而使黏液质量恶化并减少黏液分泌。因此，我们想综述MUC2的特性及其在肠道疾病中的作用，并强调进一步研究的重要性。我们还研究了MUC2在儿童和成人、溃疡性结肠炎（UC）和克罗恩病（CD）中的作用是否存在差异。
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