State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou, China.
Front Immunol. 2022 May 4;13:839460. doi: 10.3389/fimmu.2022.839460. eCollection 2022.
Bladder cancer(BC)is one of the most common urinary system tumors, which characterized by a high incidence. Polyporus polysaccharide is the main active component of polyporus, which is clinically used in the treatment of bladder cancer, but the mechanism is not clear. In previous study, we isolated homogeneous polyporus polysaccharide(HPP) with high purity from polyporus. The goal of this study was to assess the polarization of macrophages induced by HPP in the bladder tumor microenvironment and explored its anti-bladder cancer mechanism through BBN bladder cancer rat model and Tumor associated macrophages(TAM). The results suggested that HPP regulates TAM polarization to improve the tumor inflammatory microenvironment, possibly through the NF-κB/NLRP3 signaling pathway. Our results suggested that HPP may be a potential therapeutic agent for bladder tumors.
膀胱癌（BC）是最常见的泌尿系统肿瘤之一，其发病率较高。多孔菌多糖是多孔菌的主要活性成分，临床上用于膀胱癌的治疗，但作用机制尚不清楚。在之前的研究中，我们从多孔菌中分离出了具有高纯度的均一多孔菌多糖（HPP）。本研究旨在评估 HPP 在膀胱癌肿瘤微环境中诱导巨噬细胞极化的作用，并通过 BBN 膀胱癌大鼠模型和肿瘤相关巨噬细胞（TAM）探索其抗膀胱癌机制。结果表明，HPP 通过 NF-κB/NLRP3 信号通路调节 TAM 极化，改善肿瘤炎症微环境。我们的研究结果表明，HPP 可能是一种治疗膀胱癌的潜在药物。
