School of Public Health, Wuhan University, 115 Donghu Road, Wuchang District, Wuhan, Hubei 430071, People's Republic of China.
Key Laboratory of Aquaculture Facilities Engineering, Ministry of Agriculture and Rural Affairs, College of Engineering, Huazhong Agricultural University, Wuhan, Hubei 430070, People's Republic of China.
J Agric Food Chem. 2022 Jun 1;70(21):6354-6367. doi: 10.1021/acs.jafc.2c01936. Epub 2022 May 22.
Many proteins can be used to fabricate nanocarriers for encapsulation, protection, and controlled release of nutraceuticals. This review examined the protein-based nanocarriers from microscopic molecular characteristics to the macroscopical structural and functional attributes. Structural, physical, and chemical properties of protein-based nanocarriers were introduced in detail. The spatial size, shape, water dispersibility, colloidal stability, etc. of protein-based nanocarriers were largely determined by the molecular physicochemical principles of protein. Different preparative techniques, including antisolvent precipitation, pH-driven, electrospray, and gelation methods, among others, can be used to fabricate different protein-based nanocarriers. Various modifications based on physical, chemical, and enzymatic approaches can be used to improve the functional performance of these nanocarriers. Protein is a natural resource with a wide range of sources, including plant, animal, and microbial, which are usually used to fabricate the nanocarriers. Protein-based nanocarriers have many advantages in aid of the application of bioactive ingredients to the medical, food, and cosmetic industries.
许多蛋白质可用于制备纳米载体，用于封装、保护和控制营养保健品的释放。本综述从微观分子特性到宏观结构和功能属性检查了基于蛋白质的纳米载体。详细介绍了基于蛋白质的纳米载体的结构、物理和化学性质。基于蛋白质的纳米载体的空间大小、形状、水分散性、胶体稳定性等在很大程度上取决于蛋白质的分子物理化学原理。可以使用不同的制备技术，包括抗溶剂沉淀、pH 驱动、电喷雾和凝胶化方法等来制备不同的基于蛋白质的纳米载体。可以基于物理、化学和酶方法进行各种修饰，以提高这些纳米载体的功能性能。蛋白质是一种天然资源，来源广泛，包括植物、动物和微生物，通常用于制备纳米载体。基于蛋白质的纳米载体在辅助生物活性成分在医学、食品和化妆品行业中的应用方面具有许多优势。
