Molecular Biology Research Center, System Biology and Poisoning Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Department of Microbiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Appl Microbiol Biotechnol. 2022 Jun;106(11):3879-3893. doi: 10.1007/s00253-022-11940-z. Epub 2022 May 23.
It has been about a century since the discovery of the first antibiotic, and during this period, several antibiotics were produced and marketed. The production of high-potency antibiotics against infections led to victories, but these victories were temporary. Overuse and misuse of antibiotics have continued to the point that humanity today is almost helpless in the fight against infection. Researchers have predicted that by the middle of the new century, there will be a dark period after the production of antibiotics that doctors will encounter antibiotic-resistant infections for which there is no cure. Accordingly, researchers are looking for new materials with antimicrobial properties that will strengthen their ammunition to fight antibiotic-resistant infections. One of the most important alternatives to antibiotics introduced in the last three decades is antimicrobial peptides (AMPs), which affect a wide range of microbes. Due to their different antimicrobial properties from antibiotics, AMPs can fight and kill MDR, XDR, and colistin-resistant bacteria through a variety of mechanisms. Therefore, in this study, we intend to use the latest studies to give a complete description of AMPs, the importance of colistin-resistant bacteria, and their resistance mechanisms, and represent impact of AMPs on colistin-resistant bacteria. KEY POINTS: • AMPs as limited options to kill colistin-resistant bacteria. • Challenge of antibiotics resistance, colistin resistance, and mechanisms. • What is AMPs in the war with colistin-resistant bacteria?
自发现第一种抗生素以来，已经过去了大约一个世纪，在此期间，已经生产并上市了几种抗生素。生产针对感染的高活性抗生素取得了胜利，但这些胜利是暂时的。抗生素的过度和滥用仍在继续，以至于人类在对抗感染方面几乎无能为力。研究人员预测，到本世纪中叶，抗生素生产之后将出现一个黑暗时期，届时医生将遇到无法治愈的抗生素耐药性感染。因此，研究人员正在寻找具有抗菌特性的新材料，以增强他们对抗抗生素耐药性感染的武器。在过去三十年中引入的最重要的抗生素替代品之一是抗菌肽 (AMPs)，它可以影响广泛的微生物。由于 AMPs 的抗菌特性与抗生素不同，因此它们可以通过多种机制对抗和杀死 MDR、XDR 和多粘菌素耐药菌。因此，在这项研究中，我们打算利用最新的研究，全面描述 AMPs、多粘菌素耐药菌的重要性及其耐药机制，并介绍 AMPs 对多粘菌素耐药菌的影响。要点：
AMPs 是杀死多粘菌素耐药菌的有限选择。
抗生素耐药性、多粘菌素耐药性和机制的挑战。
在与多粘菌素耐药菌的战斗中什么是 AMPs？
