UT-Heart Inc., Tokyo, Japan.
Future Center Initiative, The University of Tokyo, Chiba, Japan.
Methods Mol Biol. 2022;2399:221-245. doi: 10.1007/978-1-0716-1831-8_10.
To fully understand the health and pathology of the heart, it is necessary to integrate knowledge accumulated at molecular, cellular, tissue, and organ levels. However, it is difficult to comprehend the complex interactions occurring among the building blocks of biological systems across these scales. Recent advances in computational science supported by innovative high-performance computer hardware make it possible to develop a multiscale multiphysics model simulating the heart, in which the behavior of each cell model is controlled by molecular mechanisms and the cell models themselves are arranged to reproduce elaborate tissue structures. Such a simulator could be used as a tool not only in basic science but also in clinical settings. Here, we describe a multiscale multiphysics heart simulator, UT-Heart, which uses unique technologies to realize the abovementioned features. As examples of its applications, models for cardiac resynchronization therapy and surgery for congenital heart disease will be also shown.
要全面了解心脏的健康和病理，就必须整合分子、细胞、组织和器官水平上积累的知识。然而，要理解这些尺度上生物系统组成部分之间发生的复杂相互作用却很困难。计算科学的最新进展，加上创新的高性能计算机硬件，使得开发模拟心脏的多尺度多物理模型成为可能，在这种模型中，每个细胞模型的行为都受到分子机制的控制，而细胞模型本身的排列则再现了精细的组织结构。这样的模拟器不仅可以作为基础科学的工具，也可以作为临床应用的工具。在这里，我们将介绍一个多尺度多物理心脏模拟器 UT-Heart，它使用独特的技术来实现上述功能。作为其应用的例子，还将展示心脏再同步治疗和先天性心脏病手术的模型。
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