State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Biomed Pharmacother. 2022 Jul;151:113115. doi: 10.1016/j.biopha.2022.113115. Epub 2022 May 24.
Aconitine is a diterpenoid alkaloid, which mainly exists in the plants of Aconitum. In the last decade, a plethora of studies on the pharmacological activities of aconitine has been conducted and demonstrated that aconitine possessed an extensive range of pharmacological activities such as anti-tumor, anti-inflammatory, analgesic, local anesthesia, and immunomodulatory effects. Pharmacokinetic studies indicated that aconitine may have the characteristics of poor bioavailability, wide distribution, and slow elimination. However, studies have also found that aconitine has toxic effects on the heart, nerves, embryos, etc. Therefore, we believe that aconitine may not be suitable for heart patients and pregnant women to treat related diseases. It is important to note that all of these pharmacological effects require further high-quality studies to determine the clinical efficacy of aconitine. This review aims to summarize the advances in pharmacological, pharmacokinetics, toxicity, and detoxification of aconitine in the last decade with an emphasis on its anti-tumor and anti-inflammatory activities, to provide researchers with the latest information and point out the limitations of relevant research at the current stage and the aspects that should be strengthened in future research.
乌头碱是一种二萜类生物碱，主要存在于乌头属植物中。在过去的十年中，大量研究表明乌头碱具有广泛的药理活性，如抗肿瘤、抗炎、镇痛、局部麻醉和免疫调节作用。药代动力学研究表明，乌头碱可能具有生物利用度差、分布广泛、消除缓慢的特点。然而，研究也发现乌头碱对心脏、神经、胚胎等有毒性作用。因此，我们认为乌头碱可能不适合心脏病患者和孕妇用于治疗相关疾病。需要注意的是，所有这些药理作用都需要进一步的高质量研究来确定乌头碱的临床疗效。本综述旨在总结过去十年乌头碱在药理学、药代动力学、毒性和解毒方面的进展，重点介绍其抗肿瘤和抗炎活性，为研究人员提供最新信息，并指出现阶段相关研究的局限性和未来研究中应加强的方面。
