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多基因风险评分与前瞻性多中心影像学研究评估胸痛试验（PROMISE）中冠心病表型的相关性。

Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial.

机构信息

The Leon H Charney Division of Cardiology, The Center for the Prevention of Cardiovascular Disease, New York, NY 10016.

The Leon H Charney Division of Cardiology, The Center for the Prevention of Cardiovascular Disease, New York, NY 10016.

出版信息

Am Heart J. 2022 Oct;252:12-15. doi: 10.1016/j.ahj.2022.05.012. Epub 2022 May 21.

DOI:10.1016/j.ahj.2022.05.012
PMID:35605652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9336199/
Abstract

A polygenic risk score (PGS) is associated with obstructive coronary artery disease (CAD) independent of traditional risk factors. Coronary computed tomography angiography (CTA) can characterize coronary plaques, including features of highrisk CAD. However, it is unknown if a PGS is associated with obstructive CAD and high-risk CAD phenotypes in patients with symptoms suggestive of CAD.

摘要

多基因风险评分（PGS）与传统危险因素无关，与阻塞性冠状动脉疾病（CAD）相关。冠状动脉计算机断层血管造影（CTA）可以对冠状动脉斑块进行特征分析，包括高危 CAD 的特征。但是，尚不清楚 PGS 是否与 CAD 症状患者的阻塞性 CAD 和高危 CAD 表型相关。

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本文引用的文献

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Polygenic Risk Score-Enhanced Risk Stratification of Coronary Artery Disease in Patients With Stable Chest Pain.多基因风险评分增强稳定型胸痛患者冠状动脉疾病的风险分层。
Circ Genom Precis Med. 2021 Jun;14(3):e003298. doi: 10.1161/CIRCGEN.120.003298. Epub 2021 May 25.
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Polygenic Scores to Assess Atherosclerotic Cardiovascular Disease Risk: Clinical Perspectives and Basic Implications.多基因风险评分评估动脉粥样硬化性心血管疾病风险：临床观点和基本意义。
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Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.全基因组多基因疾病风险评分可识别出与单基因突变风险相当的个体。
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Use of High-Risk Coronary Atherosclerotic Plaque Detection for Risk Stratification of Patients With Stable Chest Pain: A Secondary Analysis of the PROMISE Randomized Clinical Trial.高危冠状动脉粥样硬化斑块检测在稳定型胸痛患者风险分层中的应用：PROMISE 随机临床试验的二次分析。
JAMA Cardiol. 2018 Feb 1;3(2):144-152. doi: 10.1001/jamacardio.2017.4973.
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