多基因风险评分与前瞻性多中心影像学研究评估胸痛试验（PROMISE）中冠心病表型的相关性。
Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial.
机构信息
The Leon H Charney Division of Cardiology, The Center for the Prevention of Cardiovascular Disease, New York, NY 10016.
The Leon H Charney Division of Cardiology, The Center for the Prevention of Cardiovascular Disease, New York, NY 10016.
出版信息
Am Heart J. 2022 Oct;252:12-15. doi: 10.1016/j.ahj.2022.05.012. Epub 2022 May 21.
A polygenic risk score (PGS) is associated with obstructive coronary artery disease (CAD) independent of traditional risk factors. Coronary computed tomography angiography (CTA) can characterize coronary plaques, including features of highrisk CAD. However, it is unknown if a PGS is associated with obstructive CAD and high-risk CAD phenotypes in patients with symptoms suggestive of CAD.
多基因风险评分（PGS）与传统危险因素无关，与阻塞性冠状动脉疾病（CAD）相关。冠状动脉计算机断层血管造影（CTA）可以对冠状动脉斑块进行特征分析，包括高危 CAD 的特征。但是，尚不清楚 PGS 是否与 CAD 症状患者的阻塞性 CAD 和高危 CAD 表型相关。
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